Multi-modal data to identify key factors influencing lung injury in ARDS patients undergoing invasive mechanical ventilation: A prospective multi-center observational study protocol

Zhimei Duan; Di Lian; Kaifei Wang; Ye Hu; Han Fu; Ruoxuan Wen; Ying Zhao; Xingshuo Hu; Pan Pan; Jianqiao Xu; Jin Chen; Li Xiao; Lin Wang; Xiao Yu; Xiaobo Han; Wuxiang Xie; Fei Xie; Lixin Xie; Zhihai Han

doi:10.1371/journal.pone.0332985

Loading metrics

Open Access

Multi-modal data to identify key factors influencing lung injury in ARDS patients undergoing invasive mechanical ventilation: A prospective multi-center observational study protocol

Zhimei Duan ,

Contributed equally to this work with: Zhimei Duan, Di Lian, Kaifei Wang

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Supervision, Validation, Writing – original draft, Writing – review & editing

Affiliations College of Pulmonary and Critical Care Medicine, Chinese PLA General Hospital, Beijing, China, Naval Clinical College of Anhui Medical University, Beijing, China, The Fifth Clinical Medical College of Anhui Medical University, Hefei, China

https://orcid.org/0000-0002-6076-5406

⨯
Di Lian ,

Contributed equally to this work with: Zhimei Duan, Di Lian, Kaifei Wang

Roles Conceptualization, Data curation, Formal analysis, Investigation, Supervision, Writing – original draft, Writing – review & editing

Affiliation College of Pulmonary and Critical Care Medicine, Chinese PLA General Hospital, Beijing, China
⨯
Kaifei Wang ,

Contributed equally to this work with: Zhimei Duan, Di Lian, Kaifei Wang

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Writing – original draft, Writing – review & editing

Affiliation College of Pulmonary and Critical Care Medicine, Chinese PLA General Hospital, Beijing, China
⨯
Ye Hu,

Roles Data curation

Affiliation College of Pulmonary and Critical Care Medicine, Chinese PLA General Hospital, Beijing, China
⨯
Han Fu,

Roles Data curation

Affiliation College of Pulmonary and Critical Care Medicine, Chinese PLA General Hospital, Beijing, China
⨯
Ruoxuan Wen,

Roles Data curation

Affiliation College of Pulmonary and Critical Care Medicine, Chinese PLA General Hospital, Beijing, China
⨯
Ying Zhao,

Roles Data curation

Affiliation College of Pulmonary and Critical Care Medicine, Chinese PLA General Hospital, Beijing, China
⨯
Xingshuo Hu,

Roles Data curation

Affiliation College of Pulmonary and Critical Care Medicine, Chinese PLA General Hospital, Beijing, China
⨯
Pan Pan,

Roles Conceptualization, Data curation, Formal analysis

Affiliation College of Pulmonary and Critical Care Medicine, Chinese PLA General Hospital, Beijing, China
⨯
Jianqiao Xu,

Roles Conceptualization, Data curation, Formal analysis, Methodology

Affiliation College of Pulmonary and Critical Care Medicine, Chinese PLA General Hospital, Beijing, China
⨯
Jin Chen,

Roles Conceptualization, Data curation

Affiliation College of Pulmonary and Critical Care Medicine, Chinese PLA General Hospital, Beijing, China
⨯
Li Xiao,

Roles Conceptualization, Supervision

Affiliation College of Pulmonary and Critical Care Medicine, Chinese PLA General Hospital, Beijing, China
⨯
Lin Wang,

Roles Data curation

Affiliation College of Pulmonary and Critical Care Medicine, Chinese PLA General Hospital, Beijing, China
⨯
Xiao Yu,

Roles Data curation

Affiliation The Fifth Clinical Medical College of Anhui Medical University, Hefei, China
⨯
Xiaobo Han,

Roles Conceptualization, Data curation

Affiliation College of Pulmonary and Critical Care Medicine, Chinese PLA General Hospital, Beijing, China
⨯
Wuxiang Xie ,

Roles Conceptualization, Formal analysis, Supervision

* E-mail: xiewuxiang@hsc.pku.edu.cn (WX); xiefei0522@163.com (FX); xielx301@126.com (LX); zhihaihandoctor@163.com (ZH)

Affiliation Peking University Clinical Research Institute, Peking University Health Science Center, Beijing, China
⨯
Fei Xie ,

Roles Investigation, Methodology, Supervision

* E-mail: xiewuxiang@hsc.pku.edu.cn (WX); xiefei0522@163.com (FX); xielx301@126.com (LX); zhihaihandoctor@163.com (ZH)

Affiliation College of Pulmonary and Critical Care Medicine, Chinese PLA General Hospital, Beijing, China
⨯
Lixin Xie ,

Roles Conceptualization, Funding acquisition, Investigation, Supervision

* E-mail: xiewuxiang@hsc.pku.edu.cn (WX); xiefei0522@163.com (FX); xielx301@126.com (LX); zhihaihandoctor@163.com (ZH)

Affiliation College of Pulmonary and Critical Care Medicine, Chinese PLA General Hospital, Beijing, China
⨯
[ ... ],
Zhihai Han

Roles Conceptualization, Supervision

* E-mail: xiewuxiang@hsc.pku.edu.cn (WX); xiefei0522@163.com (FX); xielx301@126.com (LX); zhihaihandoctor@163.com (ZH)

Affiliations College of Pulmonary and Critical Care Medicine, Chinese PLA General Hospital, Beijing, China, Naval Clinical College of Anhui Medical University, Beijing, China, The Fifth Clinical Medical College of Anhui Medical University, Hefei, China
⨯
[ view all ]
[ view less ]

Multi-modal data to identify key factors influencing lung injury in ARDS patients undergoing invasive mechanical ventilation: A prospective multi-center observational study protocol

Zhimei Duan,
Di Lian,
Kaifei Wang,
Ye Hu,
Han Fu,
Ruoxuan Wen,
Ying Zhao,
Xingshuo Hu,
Pan Pan,
Jianqiao Xu

Published: January 23, 2026
https://doi.org/10.1371/journal.pone.0332985

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Acute respiratory distress syndrome
Is the Subject Area "Acute respiratory distress syndrome" applicable to this article?

Thanks for your feedback.
Transcriptome analysis
Is the Subject Area "Transcriptome analysis" applicable to this article?

Thanks for your feedback.
Prognosis
Is the Subject Area "Prognosis" applicable to this article?

Thanks for your feedback.
Metabolomics
Is the Subject Area "Metabolomics" applicable to this article?

Thanks for your feedback.
Proteomics
Is the Subject Area "Proteomics" applicable to this article?

Thanks for your feedback.
Data management
Is the Subject Area "Data management" applicable to this article?

Thanks for your feedback.
Metagenomics
Is the Subject Area "Metagenomics" applicable to this article?

Thanks for your feedback.
Respiratory physiology
Is the Subject Area "Respiratory physiology" applicable to this article?

Thanks for your feedback.