Exosomal miR-320b regulates cardiomyocyte FOXM1 expression and may serve as an early-stage compensatory mechanism in obstructive sleep apnea

Wan-yu Wang; Zhi-jia Chen; Ya-juan Lai; Lin-lin Guo; Ao Xiong; Zhen-yong Huang; Xiang-yang Yao; Yi-ming Zeng

doi:10.1371/journal.pone.0332862

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Open Access

Peer-reviewed

Research Article

Exosomal miR-320b regulates cardiomyocyte FOXM1 expression and may serve as an early-stage compensatory mechanism in obstructive sleep apnea

Wan-yu Wang,

Roles Data curation, Writing – original draft, Writing – review & editing

Affiliations Department of Pulmonary and Critical Care Medicine, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China, Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Xiamen University, Xiamen, China
⨯
Zhi-jia Chen,

Roles Data curation, Writing – original draft, Writing – review & editing

Affiliation Department of Pulmonary and Critical Care Medicine, Xiamen Haicang Hospital, Xiamen, China
⨯
Ya-juan Lai,

Roles Data curation, Writing – original draft, Writing – review & editing

Affiliations Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Xiamen University, Xiamen, China, The School of Clinical Medicine, Fujian Medical University, Fuzhou, China
⨯
Lin-lin Guo,

Roles Data curation, Formal analysis

Affiliation Department of Pulmonary and Critical Care Medicine, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China
⨯
Ao Xiong,

Roles Data curation, Formal analysis

Affiliation Department of Pulmonary and Critical Care Medicine, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China
⨯
Zhen-yong Huang,

Roles Data curation, Formal analysis

Affiliation Department of Pulmonary and Critical Care Medicine, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China
⨯
Xiang-yang Yao ,

Roles Conceptualization, Writing – review & editing

* E-mail: zeng_yi_ming@126.com, 13599513293@163.com (Y-mZ); tobyyo2000@163.com (X-yY)

Affiliations The School of Clinical Medicine, Fujian Medical University, Fuzhou, China, Department of Pulmonary Diseases, Xinglin Hospital of Xiamen, Xiamen, China
⨯
Yi-ming Zeng

Roles Conceptualization, Writing – review & editing

* E-mail: zeng_yi_ming@126.com, 13599513293@163.com (Y-mZ); tobyyo2000@163.com (X-yY)

Affiliation Department of Pulmonary and Critical Care Medicine, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China

https://orcid.org/0000-0001-5635-3006

⨯

Exosomal miR-320b regulates cardiomyocyte FOXM1 expression and may serve as an early-stage compensatory mechanism in obstructive sleep apnea

Wan-yu Wang,
Zhi-jia Chen,
Ya-juan Lai,
Lin-lin Guo,
Ao Xiong,
Zhen-yong Huang,
Xiang-yang Yao,
Yi-ming Zeng

Published: September 26, 2025
https://doi.org/10.1371/journal.pone.0332862

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Exosomes
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Gene expression
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Transfection
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MicroRNAs
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