Predicting severe renal dysfunction in alcohol-associated cirrhosis: Comparative performance of liver function scores and machine learning models

Julian Müller-Kühnle; Moritz Schanz; Severin Schricker; Christian Benignus; Julia Todoroff; Jörg Latus; Wolfram Zoller; Dominik Marschner

doi:10.1371/journal.pone.0332840

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Open Access

Peer-reviewed

Research Article

Predicting severe renal dysfunction in alcohol-associated cirrhosis: Comparative performance of liver function scores and machine learning models

Julian Müller-Kühnle ,

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Methodology, Project administration, Resources, Software, Validation, Visualization, Writing – original draft

* E-mail: julian.mueller-kuehnle@rbk.de

Affiliations Department of General Internal Medicine and Nephrology, Robert Bosch Hospital, Stuttgart, Germany, Robert Bosch Society for Medical Research, Stuttgart, Germany, Paracelsus Medical University, Salzburg, Austria

https://orcid.org/0009-0005-8849-5101

⨯
Moritz Schanz,

Roles Writing – review & editing

Affiliation Department of General Internal Medicine and Nephrology, Robert Bosch Hospital, Stuttgart, Germany
⨯
Severin Schricker,

Roles Methodology, Writing – review & editing

Affiliation Department of General Internal Medicine and Nephrology, Robert Bosch Hospital, Stuttgart, Germany
⨯
Christian Benignus,

Roles Formal analysis, Writing – review & editing

Affiliations Paracelsus Medical University, Salzburg, Austria, Department of General, Visceral, Thoracic, and Pediatric Surgery, Ludwigsburg Hospital, Ludwigsburg, Germany
⨯
Julia Todoroff,

Roles Data curation, Formal analysis, Writing – review & editing

Affiliation Department of Hematology, Oncology, Stem Cell Transplantation, and Palliative Medicine, Klinikum Stuttgart, Stuttgart, Germany
⨯
Jörg Latus,

Roles Supervision, Writing – review & editing

Affiliation Department of General Internal Medicine and Nephrology, Robert Bosch Hospital, Stuttgart, Germany
⨯
Wolfram Zoller,

Roles Supervision, Writing – review & editing

Affiliation Department of General Internal Medicine, Gastroenterology, Gastrointestinal Oncology, Hepatology, Infectious Diseases, and Pulmonology, Klinikum Stuttgart, Stuttgart, Germany
⨯
Dominik Marschner

Roles Data curation, Formal analysis, Writing – review & editing

Affiliation Department of Hematology, Oncology, Stem Cell Transplantation, and Palliative Medicine, Klinikum Stuttgart, Stuttgart, Germany
⨯

Predicting severe renal dysfunction in alcohol-associated cirrhosis: Comparative performance of liver function scores and machine learning models

Julian Müller-Kühnle,
Moritz Schanz,
Severin Schricker,
Christian Benignus,
Julia Todoroff,
Jörg Latus,
Wolfram Zoller,
Dominik Marschner

Published: September 17, 2025
https://doi.org/10.1371/journal.pone.0332840

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Chronic kidney disease
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Creatinine
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Cirrhosis
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Renal system
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Glomerular filtration rate
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Liver diseases
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Urea
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Alcoholics
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