Effect of intermittent extracellular low-pH environment on human umbilical vein endothelial cell activity

Ryota Nishida; Tomoaki Fukui; Kenichi Sawauchi; Yohei Kumabe; Hyuma Kondo; Yuya Yamamoto; Kyohei Takase; Ryo Yoshikawa; Takahiro Niikura; Ryosuke Kuroda; Keisuke Oe

doi:10.1371/journal.pone.0332673

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Open Access

Peer-reviewed

Research Article

Effect of intermittent extracellular low-pH environment on human umbilical vein endothelial cell activity

Ryota Nishida,

Roles Formal analysis, Investigation, Methodology, Writing – original draft

Affiliation Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan

https://orcid.org/0000-0002-8681-2522

⨯
Tomoaki Fukui,

Roles Funding acquisition, Project administration, Validation, Writing – review & editing

Affiliation Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
⨯
Kenichi Sawauchi,

Roles Conceptualization

Affiliation Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
⨯
Yohei Kumabe,

Roles Validation

Affiliation Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
⨯
Hyuma Kondo,

Roles Validation

Affiliation Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
⨯
Yuya Yamamoto,

Roles Validation

Affiliation Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
⨯
Kyohei Takase,

Roles Validation

Affiliation Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
⨯
Ryo Yoshikawa,

Roles Validation

Affiliation Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan

https://orcid.org/0000-0003-4123-0286

⨯
Takahiro Niikura,

Roles Supervision

Affiliation Department of Orthopaedic Surgery, Hyogo Prefectural Nishinomiya Hospital, Hyogo, Japan
⨯
Ryosuke Kuroda,

Roles Funding acquisition, Supervision

Affiliation Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
⨯
Keisuke Oe

Roles Conceptualization, Funding acquisition, Project administration, Supervision

* E-mail: keisukeo@med.kobe-u.ac.jp

Affiliation Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan

https://orcid.org/0000-0001-9992-4550

⨯

Effect of intermittent extracellular low-pH environment on human umbilical vein endothelial cell activity

Ryota Nishida,
Tomoaki Fukui,
Kenichi Sawauchi,
Yohei Kumabe,
Hyuma Kondo,
Yuya Yamamoto,
Kyohei Takase,
Ryo Yoshikawa,
Takahiro Niikura,
Ryosuke Kuroda

Published: September 16, 2025
https://doi.org/10.1371/journal.pone.0332673

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