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No evidence of direct activation of human neutrophil responses by multivalent prefusion trimeric SARS-CoV-2 Spike protein ex vivo
- Audray Fortin ,
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Sandrine Huot ,
Contributed equally to this work with: Audray Fortin, Sandrine Huot
Roles Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – review & editing
Affiliations Division of Infectious and Immune Diseases, Centre de Recherche du Centre Hospitalier Universitaire de Québec-Université Laval, Quebec City, Canada, Department of microbiology, Infectious disease and immunology, Faculty of Medicine, Université Laval, Quebec City, Canada
⨯ - Elise Caron,
- Cynthia Laflamme,
- Amélie Pagliuzza,
-
Nicolas Chomont,
Roles Supervision, Writing – review & editing
Affiliations Centre de recherche du Centre Hospitalier de l’Université de Montréal (CRCHUM), Montreal, Quebec, Canada, Department of microbiology, Infectiology and immunology, Faculty of medicine, Université de Montréal, Montreal, Canada
⨯ -
Caroline Gilbert,
Roles Formal analysis, Methodology, Writing – review & editing
Affiliations Division of Infectious and Immune Diseases, Centre de Recherche du Centre Hospitalier Universitaire de Québec-Université Laval, Quebec City, Canada, Department of microbiology, Infectious disease and immunology, Faculty of Medicine, Université Laval, Quebec City, Canada
⨯ - Baoshan Zhang,
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Peter D. Kwong,
Roles Resources, Writing – review & editing
Affiliations Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America, Department of Biochemistry and Molecular Biophysics and Aaron Diamond Research Center, Columbia University, New York, New York, United States of America
⨯ -
Marc Pouliot ,
Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing
* E-mail: nathalie.grandvaux@umontreal.ca (NG); marc.pouliot@crchudequebec.ulaval.ca (MP)
¶‡ These authors contributed equally to this work.
Affiliations Division of Infectious and Immune Diseases, Centre de Recherche du Centre Hospitalier Universitaire de Québec-Université Laval, Quebec City, Canada, Department of microbiology, Infectious disease and immunology, Faculty of Medicine, Université Laval, Quebec City, Canada
⨯ -
Nathalie Grandvaux
Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Project administration, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing
* E-mail: nathalie.grandvaux@umontreal.ca (NG); marc.pouliot@crchudequebec.ulaval.ca (MP)
¶‡ These authors contributed equally to this work.
Affiliations Centre de recherche du Centre Hospitalier de l’Université de Montréal (CRCHUM), Montreal, Quebec, Canada, Department of biochemistry and molecular medicine, Faculty of medicine, Université de Montréal, Montreal, Canada
⨯
https://orcid.org/0009-0006-8332-8555
No evidence of direct activation of human neutrophil responses by multivalent prefusion trimeric SARS-CoV-2 Spike protein ex vivo
- Audray Fortin,
- Sandrine Huot,
- Elise Caron,
- Cynthia Laflamme,
- Amélie Pagliuzza,
- Nicolas Chomont,
- Caroline Gilbert,
- Baoshan Zhang,
- Peter D. Kwong,
- Marc Pouliot
- Published: October 29, 2025
- https://doi.org/10.1371/journal.pone.0332261