Associations of high-risk drug patterns with mortality among community-dwelling older adults: A 23-year prospective cohort study

Liat Orenstein; Angela Chetrit; Ronen Fluss; Keren Laufer; Moyses Szklo; Rachel Dankner

doi:10.1371/journal.pone.0332210

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Open Access

Peer-reviewed

Research Article

Associations of high-risk drug patterns with mortality among community-dwelling older adults: A 23-year prospective cohort study

Liat Orenstein,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliations Public Health Research Center, Gertner Institute for Epidemiology and Health Policy Research, Sheba Medical Center, Ramat-Gan, Israel, Department of Epidemiology and Preventive Medicine, School of Public Health, Gray Faculty of Medical and Health Sciences, Tel-Aviv University, Tel-Aviv, Israel

https://orcid.org/0000-0001-9464-9123

⨯
Angela Chetrit,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliation Public Health Research Center, Gertner Institute for Epidemiology and Health Policy Research, Sheba Medical Center, Ramat-Gan, Israel
⨯
Ronen Fluss,

Roles Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation Biostatistics and Biomathematics Unit, Gertner Institute for Epidemiology and Health Policy Research, Sheba Medical Center, Ramat-Gan, Israel
⨯
Keren Laufer,

Roles Investigation, Methodology, Writing – review & editing

Affiliation Pharmaceutics Registration Department, Teva Israel Ltd., Shoham, Israel
⨯
Moyses Szklo ,

Roles Investigation, Methodology, Writing – review & editing

¶☯ Joint last author.

Affiliation Department of Epidemiology, the Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America
⨯
Rachel Dankner

Roles Conceptualization, Data curation, Funding acquisition, Investigation, Methodology, Supervision, Writing – review & editing

* E-mail: racheld@gertner.health.gov.il

¶☯ Joint last author.

Affiliations Public Health Research Center, Gertner Institute for Epidemiology and Health Policy Research, Sheba Medical Center, Ramat-Gan, Israel, Department of Epidemiology and Preventive Medicine, School of Public Health, Gray Faculty of Medical and Health Sciences, Tel-Aviv University, Tel-Aviv, Israel
⨯

Associations of high-risk drug patterns with mortality among community-dwelling older adults: A 23-year prospective cohort study

Liat Orenstein,
Angela Chetrit,
Ronen Fluss,
Keren Laufer,
Moyses Szklo,
Rachel Dankner

Published: September 11, 2025
https://doi.org/10.1371/journal.pone.0332210

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