Utility of enhanced recovery after surgery protocols in reducing postoperative opioid use across different surgical specialties—An analysis of Iowa’s billion pill pledge program

Wali U. Pirzada; Simran Shamith; Roland N. Leyson; Sara A. Khan; Sina Ramtin; Asif M. Ilyas

doi:10.1371/journal.pone.0332205

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Open Access

Peer-reviewed

Research Article

Utility of enhanced recovery after surgery protocols in reducing postoperative opioid use across different surgical specialties—An analysis of Iowa’s billion pill pledge program

Wali U. Pirzada,

Roles Conceptualization, Data curation, Formal analysis, Methodology, Software, Validation, Writing – original draft, Writing – review & editing

Affiliations Rothman Opioid Foundation, Philadelphia, Pennsylvania, United States of America, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Simran Shamith,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Writing – review & editing

Affiliation Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Roland N. Leyson,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Writing – review & editing

Affiliation Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Sara A. Khan,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Writing – review & editing

Affiliation Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Sina Ramtin ,

Roles Conceptualization, Investigation, Methodology, Software, Supervision, Validation, Writing – review & editing

* E-mail: Sina.ramtin@austin.utexas.edu

Affiliations Rothman Opioid Foundation, Philadelphia, Pennsylvania, United States of America, University of Texas, Austin, Texas, United States of America

https://orcid.org/0000-0001-5197-6204

⨯
Asif M. Ilyas

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Supervision, Writing – review & editing

Affiliations Rothman Opioid Foundation, Philadelphia, Pennsylvania, United States of America, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America, Rothman Orthopaedic Institute, Philadelphia, Pennsylvania, United States of America
⨯

Utility of enhanced recovery after surgery protocols in reducing postoperative opioid use across different surgical specialties—An analysis of Iowa’s billion pill pledge program

Wali U. Pirzada,
Simran Shamith,
Roland N. Leyson,
Sara A. Khan,
Sina Ramtin,
Asif M. Ilyas

Published: September 19, 2025
https://doi.org/10.1371/journal.pone.0332205

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