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Open Access

Peer-reviewed

Research Article

Investigating the anti-osteosarcoma effects of Patchouli alcohol through protein network mapping and in vitro experiments

Zeyu Zhan ,

Contributed equally to this work with: Zeyu Zhan, He Pang

Roles Formal analysis, Software, Supervision, Writing – original draft

Affiliation Orthopedics Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China
⨯
He Pang ,

Contributed equally to this work with: Zeyu Zhan, He Pang

Roles Formal analysis, Software, Writing – original draft

Affiliation Orthopedics Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China

https://orcid.org/0000-0002-4736-1191

⨯
Hang Wu,

Roles Software, Visualization

Affiliation Orthopedics Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China
⨯
Lijun Song ,

Roles Funding acquisition, Methodology, Writing – review & editing

* E-mail: lijunsong0369@163.com (LS); webjxmc@163.com (BW)

Affiliation Reproductive Medicine Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China
⨯
Bo Wei

Roles Funding acquisition, Methodology, Project administration, Writing – review & editing

* E-mail: lijunsong0369@163.com (LS); webjxmc@163.com (BW)

Affiliation Orthopedics Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China
⨯

Investigating the anti-osteosarcoma effects of Patchouli alcohol through protein network mapping and in vitro experiments

Zeyu Zhan,
He Pang,
Hang Wu,
Lijun Song,
Bo Wei

x

Published: September 24, 2025
https://doi.org/10.1371/journal.pone.0332202

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Apoptosis
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Osteosarcoma cells
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Osteosarcoma
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Autophagic cell death
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Cancer treatment
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Computer software
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Hydrogen bonding
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Molecular docking
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