Genotype-phenotype correlations of germline mutations in exon 10 of the RET proto-oncogene from 14 MEN2A families of Ethnic Han Chinese

Feng Li; Weiying Chen; Zhenyu Chen; Bijun Lian; Xudong Fang; Hangyang Jin; Huihong Wang; Jianqiang Zhao; Yiming Zhang; Xiaoping Qi

doi:10.1371/journal.pone.0332136

Loading metrics

Open Access

Peer-reviewed

Research Article

Genotype-phenotype correlations of germline mutations in exon 10 of the RET proto-oncogene from 14 MEN2A families of Ethnic Han Chinese

Feng Li ,

Contributed equally to this work with: Feng Li, Weiying Chen, Zhenyu Chen

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Writing – original draft

Affiliations Department of Oncologic and Urologic Surgery, The 903rd PLA Hospital, Hangzhou Medical College, Hangzhou, Zhejiang Province, China, Department of Urology, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Enze Hospital of Hangzhou Medical College, Taizhou Enze Medical Center (Group), Taizhou, Zhejiang Province, China
⨯
Weiying Chen ,

Contributed equally to this work with: Feng Li, Weiying Chen, Zhenyu Chen

Roles Funding acquisition

Affiliation Department of Urology, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Enze Hospital of Hangzhou Medical College, Taizhou Enze Medical Center (Group), Taizhou, Zhejiang Province, China
⨯
Zhenyu Chen ,

Contributed equally to this work with: Feng Li, Weiying Chen, Zhenyu Chen

Roles Formal analysis

Affiliation Department of Urology, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Enze Hospital of Hangzhou Medical College, Taizhou Enze Medical Center (Group), Taizhou, Zhejiang Province, China
⨯
Bijun Lian,

Roles Data curation, Formal analysis

Affiliation Department of Oncologic and Urologic Surgery, The 903rd PLA Hospital, Hangzhou Medical College, Hangzhou, Zhejiang Province, China
⨯
Xudong Fang,

Roles Writing – original draft

Affiliation Department of Oncologic and Urologic Surgery, The 903rd PLA Hospital, Hangzhou Medical College, Hangzhou, Zhejiang Province, China
⨯
Hangyang Jin,

Roles Data curation

Affiliation Department of Oncologic and Urologic Surgery, The 903rd PLA Hospital, Hangzhou Medical College, Hangzhou, Zhejiang Province, China
⨯
Huihong Wang,

Roles Data curation

Affiliation Department of Oncologic and Urologic Surgery, The 903rd PLA Hospital, Hangzhou Medical College, Hangzhou, Zhejiang Province, China
⨯
Jianqiang Zhao,

Roles Data curation

Affiliation Department of Head and Neck Surgery, Zhejiang Cancer Hospital, Hangzhou, Zhejiang Province, China
⨯
Yiming Zhang ,

Roles Writing – review & editing

* E-mail: qxplmd@163.com (QX); hz117zym@163.com (YZ)

Affiliation Department of Oncologic and Urologic Surgery, The 903rd PLA Hospital, Hangzhou Medical College, Hangzhou, Zhejiang Province, China
⨯
Xiaoping Qi

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Writing – original draft, Writing – review & editing

* E-mail: qxplmd@163.com (QX); hz117zym@163.com (YZ)

Affiliations Department of Oncologic and Urologic Surgery, The 903rd PLA Hospital, Hangzhou Medical College, Hangzhou, Zhejiang Province, China, Department of Urology, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Enze Hospital of Hangzhou Medical College, Taizhou Enze Medical Center (Group), Taizhou, Zhejiang Province, China

https://orcid.org/0000-0003-1543-0727

⨯

Genotype-phenotype correlations of germline mutations in exon 10 of the RET proto-oncogene from 14 MEN2A families of Ethnic Han Chinese

Feng Li,
Weiying Chen,
Zhenyu Chen,
Bijun Lian,
Xudong Fang,
Hangyang Jin,
Huihong Wang,
Jianqiang Zhao,
Yiming Zhang,
Xiaoping Qi

Published: September 11, 2025
https://doi.org/10.1371/journal.pone.0332136

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Mutation
Is the Subject Area "Mutation" applicable to this article?

Thanks for your feedback.
Cancer detection and diagnosis
Is the Subject Area "Cancer detection and diagnosis" applicable to this article?

Thanks for your feedback.
Point mutation
Is the Subject Area "Point mutation" applicable to this article?

Thanks for your feedback.
Thyroid
Is the Subject Area "Thyroid" applicable to this article?

Thanks for your feedback.
Metastasis
Is the Subject Area "Metastasis" applicable to this article?

Thanks for your feedback.
Surgical and invasive medical procedures
Is the Subject Area "Surgical and invasive medical procedures" applicable to this article?

Thanks for your feedback.
Lymph nodes
Is the Subject Area "Lymph nodes" applicable to this article?

Thanks for your feedback.
Thyroid carcinoma
Is the Subject Area "Thyroid carcinoma" applicable to this article?

Thanks for your feedback.