HLX and SLC25A20: Immunologic regulators bridging ankylosing spondylitis and uveitis via multi-omics integration and machine learning

Weiming Cai; Huayan Chen; Dong Huang; Xiaoli Ma; Dongbo Jiang; Tangming Guan

doi:10.1371/journal.pone.0332049

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Open Access

Peer-reviewed

Research Article

HLX and SLC25A20: Immunologic regulators bridging ankylosing spondylitis and uveitis via multi-omics integration and machine learning

Weiming Cai ,

Contributed equally to this work with: Weiming Cai, Huayan Chen

Roles Data curation, Formal analysis, Methodology

Affiliations Department of Pharmacy, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong Province, China, Laboratory of Clinical Pharmacy, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong Province, China
⨯
Huayan Chen ,

Contributed equally to this work with: Weiming Cai, Huayan Chen

Roles Methodology, Validation, Visualization

Affiliation Department of Pharmacy, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong Province, China
⨯
Dong Huang,

Roles Formal analysis, Methodology, Software

Affiliation Department of Pharmacy, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong Province, China
⨯
Xiaoli Ma,

Roles Data curation, Formal analysis, Methodology

Affiliation Department of Pharmacy, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong Province, China
⨯
Dongbo Jiang ,

Roles Conceptualization, Project administration, Supervision

* E-mail: guantm@gdmu.edu.cn (TG); 13702889558@163.com (DJ)

Affiliation Department of Pharmacy, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong Province, China
⨯
Tangming Guan

Roles Funding acquisition, Project administration, Supervision, Validation, Writing – original draft, Writing – review & editing

* E-mail: guantm@gdmu.edu.cn (TG); 13702889558@163.com (DJ)

Affiliations Department of Pharmacy, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong Province, China, Laboratory of Clinical Pharmacy, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong Province, China

https://orcid.org/0000-0002-4617-8221

⨯

HLX and SLC25A20: Immunologic regulators bridging ankylosing spondylitis and uveitis via multi-omics integration and machine learning

Weiming Cai,
Huayan Chen,
Dong Huang,
Xiaoli Ma,
Dongbo Jiang,
Tangming Guan

Published: September 10, 2025
https://doi.org/10.1371/journal.pone.0332049

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Uveitis
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Ankylosing spondylitis
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