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Open Access

Peer-reviewed

Research Article

LAMP2A-dependent chaperone-mediated autophagy enhances oxidative stress resistance in gastric cancer cells through selective degradation of accumulated oxidized DJ-1

Shuangshuang Le ,

Contributed equally to this work with: Shuangshuang Le, Tongtong Guo

Roles Conceptualization, Investigation, Methodology

Affiliation Department of Oncology, 904 Hospital of PLA Joint Logistic Support Force, Wuxi, China
⨯
Tongtong Guo ,

Contributed equally to this work with: Shuangshuang Le, Tongtong Guo

Roles Investigation, Methodology

Affiliation School of Life Sciences, Hubei University, Wuhan, Hubei, China
⨯
Meng Yang,

Roles Data curation

Affiliation Department of Oncology, 904 Hospital of PLA Joint Logistic Support Force, Wuxi, China
⨯
Tianjuan Tang,

Roles Data curation

Affiliation Department of Gastroenterology, 904 Hospital of PLA Joint Logistic Support Force, Wuxi, China
⨯
Zhijie Liu,

Roles Formal analysis

Affiliation Department of Anesthesiology, 904 Hospital of PLA Joint Logistic Support Force, Wuxi, China
⨯
Yang Zheng ,

Roles Funding acquisition

* E-mail: pmg575626@163.com (MP); zhengycloud@163.com (YZ)

Affiliation Department of Gastroenterology, 904 Hospital of PLA Joint Logistic Support Force, Wuxi, China
⨯
Maogui Pang

Roles Conceptualization, Methodology

* E-mail: pmg575626@163.com (MP); zhengycloud@163.com (YZ)

Affiliation Department of Gastroenterology, 904 Hospital of PLA Joint Logistic Support Force, Wuxi, China

https://orcid.org/0000-0002-1192-2655

⨯

LAMP2A-dependent chaperone-mediated autophagy enhances oxidative stress resistance in gastric cancer cells through selective degradation of accumulated oxidized DJ-1

Shuangshuang Le,
Tongtong Guo,
Meng Yang,
Tianjuan Tang,
Zhijie Liu,
Yang Zheng,
Maogui Pang

x

Published: May 15, 2026
https://doi.org/10.1371/journal.pone.0331823

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Gastric cancer
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Oxidative stress
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Apoptosis
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Cancer treatment
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Autophagic cell death
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Lysosomes
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Antioxidants
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Non-small cell lung cancer
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