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Open Access
Study Protocol
Chest drain REgular FLushing in ComplIcated parapneumonic EFfusions and empyemas: Study protocol for the RELIEF randomized controlled trial
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Taryn K. Boyle ,
Contributed equally to this work with: Taryn K. Boyle, Jennifer D. Duke
Roles Investigation, Methodology, Project administration, Writing – original draft, Writing – review & editing
Affiliation Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
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Jennifer D. Duke ,
Contributed equally to this work with: Taryn K. Boyle, Jennifer D. Duke
Roles Conceptualization, Data curation, Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing
Affiliation Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
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Gulmira Yermakhanova,
Roles Project administration, Writing – original draft, Writing – review & editing
Affiliation Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
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Rafael Paez,
Roles Investigation, Writing – original draft, Writing – review & editing
Affiliation Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
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Greta Bridwell,
Roles Investigation, Writing – original draft, Writing – review & editing
Affiliation Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
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Ankush P. Ratwani,
Roles Investigation, Writing – original draft, Writing – review & editing
Affiliation Creighton University, Division of Pulmonary, Critical Care, and Sleep Medicine, Omaha, Nebraska, United States of America
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Kaele M. Leonard,
Roles Investigation, Writing – original draft, Writing – review & editing
Affiliation Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
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Heidi Chen,
Roles Methodology, Writing – original draft, Writing – review & editing
Affiliation Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
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Frank E. Harrell Jr,
Roles Methodology, Writing – original draft, Writing – review & editing
Affiliation Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
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Robert J. Lentz,
Roles Conceptualization, Investigation, Methodology, Writing – original draft, Writing – review & editing
Affiliation Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
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Fabien Maldonado,
Roles Conceptualization, Investigation, Methodology, Writing – original draft, Writing – review & editing
Affiliation Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
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Najib M. Rahman,
Roles Conceptualization, Investigation, Methodology, Writing – original draft, Writing – review & editing
Affiliation Oxford Respiratory Trials Unit, Oxford NIHR Biomedical Research Centre for Respiratory Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
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Samira Shojaee
Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing
* E-mail: samira.shojaee@vumc.org
Affiliation Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
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Chest drain REgular FLushing in ComplIcated parapneumonic EFfusions and empyemas: Study protocol for the RELIEF randomized controlled trial
- Taryn K. Boyle,
- Jennifer D. Duke,
- Gulmira Yermakhanova,
- Rafael Paez,
- Greta Bridwell,
- Ankush P. Ratwani,
- Kaele M. Leonard,
- Heidi Chen,
- Frank E. Harrell Jr,
- Robert J. Lentz
- Published: March 5, 2026
- https://doi.org/10.1371/journal.pone.0331725