Metabolomics-guided machine learning reveals diagnostic and mechanistic biomarkers in CHB with MASLD

Chuyang Wang; Yutao Chen; Huanming Xiao; Jianxiong Cai; Ruihua Wang; Xuan Zeng; Ming Lin; Wofeng Liu; Xiaoling Chi; Qubo Chen

doi:10.1371/journal.pone.0331529

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Open Access

Peer-reviewed

Research Article

Metabolomics-guided machine learning reveals diagnostic and mechanistic biomarkers in CHB with MASLD

Chuyang Wang,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Software, Validation, Writing – original draft

Affiliations Biological Resource Center, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China, State Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
⨯
Yutao Chen,

Roles Formal analysis, Investigation, Validation

Affiliations Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China, Guangzhou University of Chinese Medicine, Guangzhou, China
⨯
Huanming Xiao,

Roles Resources

Affiliation The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
⨯
Jianxiong Cai,

Roles Resources

Affiliation The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
⨯
Ruihua Wang,

Roles Resources

Affiliation The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
⨯
Xuan Zeng,

Roles Data curation

Affiliations Biological Resource Center, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China, State Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
⨯
Ming Lin,

Roles Visualization

Affiliation The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
⨯
Wofeng Liu,

Roles Resources

Affiliation Biological Resource Center, Guangzhou People’s Hospital, Guangzhou, China
⨯
Xiaoling Chi ,

Roles Project administration, Supervision, Writing – review & editing

* E-mail: qubochen326@126.com (QC); chixiaolingqh@163.com (XC)

Affiliations State Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
⨯
Qubo Chen

Roles Funding acquisition, Project administration, Supervision, Writing – review & editing

* E-mail: qubochen326@126.com (QC); chixiaolingqh@163.com (XC)

Affiliations Biological Resource Center, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China, State Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China

https://orcid.org/0000-0003-2059-8217

⨯

Metabolomics-guided machine learning reveals diagnostic and mechanistic biomarkers in CHB with MASLD

Chuyang Wang,
Yutao Chen,
Huanming Xiao,
Jianxiong Cai,
Ruihua Wang,
Xuan Zeng,
Ming Lin,
Wofeng Liu,
Xiaoling Chi,
Qubo Chen

Published: February 11, 2026
https://doi.org/10.1371/journal.pone.0331529

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