Charantin targets HMGCR-PCSK9 axis and activates PPAR-α signaling to ameliorate hyperlipidemia: Mechanistic insights from bioinformatics and in-vivo studies

Ghulam Abbas; Muhammad Nasir Hayat Malik; Haya Yasin; Saud O. Alshammari; Ghulam Murtaza; Waseem Hassan; Muhammad Atif; Ramla Shabbir

doi:10.1371/journal.pone.0331356

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Open Access

Peer-reviewed

Research Article

Charantin targets HMGCR-PCSK9 axis and activates PPAR-α signaling to ameliorate hyperlipidemia: Mechanistic insights from bioinformatics and in-vivo studies

Ghulam Abbas,

Roles Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft

Affiliation Faculty of Pharmacy, The University of Lahore, Lahore, Punjab, Pakistan
⨯
Muhammad Nasir Hayat Malik ,

Roles Conceptualization, Data curation, Formal analysis, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – review & editing

* E-mail: Nasir.hayat@pharm.uol.edu.pk (MNHM); haya.yasin@gmail.com (HY)

Affiliation Faculty of Pharmacy, The University of Lahore, Lahore, Punjab, Pakistan

https://orcid.org/0000-0002-2657-9810

⨯
Haya Yasin ,

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Software, Validation, Visualization, Writing – review & editing

* E-mail: Nasir.hayat@pharm.uol.edu.pk (MNHM); haya.yasin@gmail.com (HY)

Affiliation Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Ajman University, Ajman, United Arab Emirates

https://orcid.org/0000-0002-1262-2507

⨯
Saud O. Alshammari,

Roles Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – review & editing

Affiliation Department of Pharmacognosy and Alternative Medicine, College of Pharmacy, Northern Border University, Rafha, Saudi Arabia
⨯
Ghulam Murtaza,

Roles Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – review & editing

Affiliation Department of Pharmacy, COMSATS University Islamabad, Lahore, Punjab, Pakistan
⨯
Waseem Hassan,

Roles Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – review & editing

Affiliation Department of Pharmacy, COMSATS University Islamabad, Lahore, Punjab, Pakistan

https://orcid.org/0000-0002-0197-1736

⨯
Muhammad Atif,

Roles Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – review & editing

Affiliation Faculty of Pharmacy, The University of Lahore, Lahore, Punjab, Pakistan
⨯
Ramla Shabbir

Roles Data curation, Formal analysis, Investigation, Methodology, Resources, Software, Validation, Visualization, Writing – review & editing

Affiliation Faculty of Pharmacy, The University of Lahore, Lahore, Punjab, Pakistan
⨯

Charantin targets HMGCR-PCSK9 axis and activates PPAR-α signaling to ameliorate hyperlipidemia: Mechanistic insights from bioinformatics and in-vivo studies

Ghulam Abbas,
Muhammad Nasir Hayat Malik,
Haya Yasin,
Saud O. Alshammari,
Ghulam Murtaza,
Waseem Hassan,
Muhammad Atif,
Ramla Shabbir

Published: September 2, 2025
https://doi.org/10.1371/journal.pone.0331356

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Hyperlipidemia
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Lipids
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