Vitamin D3 reduces the viability of cancer cells in vitro and retard the EAC tumors growth in mice

Vidya G. Bettada; Chaithanya G. Basavaraju; Shalini H. Doreswamy; SubbaRao V. Tulimilli; Rimshia Naaz; Siva Dallavalasa; Paramahans V. Salimath; Anjali Devi S. Bettadapura; Asha Srinivasan; Rajalakshmi Ramashetty; Suma M. Natraj; SubbaRao V. Madhunapantula

doi:10.1371/journal.pone.0331306

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Open Access

Peer-reviewed

Research Article

Vitamin D3 reduces the viability of cancer cells in vitro and retard the EAC tumors growth in mice

Vidya G. Bettada,

Roles Conceptualization, Data curation, Formal analysis, Methodology, Software, Writing – original draft

Affiliation Center of Excellence in Molecular Biology and Regenerative Medicine (CEMR) Laboratory (DST-FIST supported center, ICMR collaborating center of excellence – ICMR-CCoE), Department of Biochemistry (DST-FIST supported department), JSS Medical College, JSS Academy of Higher Education & Research (JSS AHER), Mysuru, Karnataka, India
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Chaithanya G. Basavaraju,

Roles Data curation, Methodology

Affiliation Center of Excellence in Molecular Biology and Regenerative Medicine (CEMR) Laboratory (DST-FIST supported center, ICMR collaborating center of excellence – ICMR-CCoE), Department of Biochemistry (DST-FIST supported department), JSS Medical College, JSS Academy of Higher Education & Research (JSS AHER), Mysuru, Karnataka, India
⨯
Shalini H. Doreswamy,

Roles Formal analysis, Investigation

Affiliations Center of Excellence in Molecular Biology and Regenerative Medicine (CEMR) Laboratory (DST-FIST supported center, ICMR collaborating center of excellence – ICMR-CCoE), Department of Biochemistry (DST-FIST supported department), JSS Medical College, JSS Academy of Higher Education & Research (JSS AHER), Mysuru, Karnataka, India, Division of Nanoscience and Technology, School of Life Sciences-Mysuru, JSS Academy of Higher Education & Research (JSS AHER), Mysuru, Karnataka, India
⨯
SubbaRao V. Tulimilli,

Roles Data curation, Software, Writing – original draft

Affiliation Center of Excellence in Molecular Biology and Regenerative Medicine (CEMR) Laboratory (DST-FIST supported center, ICMR collaborating center of excellence – ICMR-CCoE), Department of Biochemistry (DST-FIST supported department), JSS Medical College, JSS Academy of Higher Education & Research (JSS AHER), Mysuru, Karnataka, India

https://orcid.org/0000-0002-4743-8814

⨯
Rimshia Naaz,

Roles Data curation, Software, Writing – original draft

Affiliation Center of Excellence in Molecular Biology and Regenerative Medicine (CEMR) Laboratory (DST-FIST supported center, ICMR collaborating center of excellence – ICMR-CCoE), Department of Biochemistry (DST-FIST supported department), JSS Medical College, JSS Academy of Higher Education & Research (JSS AHER), Mysuru, Karnataka, India
⨯
Siva Dallavalasa,

Roles Data curation, Resources

Affiliation Center of Excellence in Molecular Biology and Regenerative Medicine (CEMR) Laboratory (DST-FIST supported center, ICMR collaborating center of excellence – ICMR-CCoE), Department of Biochemistry (DST-FIST supported department), JSS Medical College, JSS Academy of Higher Education & Research (JSS AHER), Mysuru, Karnataka, India
⨯
Paramahans V. Salimath,

Roles Funding acquisition, Validation

Affiliation JSS Academy of Higher Education & Research (JSS AHER), Mysuru, Karnataka, India
⨯
Anjali Devi S. Bettadapura,

Roles Resources, Validation

Affiliation Center of Excellence in Molecular Biology and Regenerative Medicine (CEMR) Laboratory (DST-FIST supported center, ICMR collaborating center of excellence – ICMR-CCoE), Department of Biochemistry (DST-FIST supported department), JSS Medical College, JSS Academy of Higher Education & Research (JSS AHER), Mysuru, Karnataka, India
⨯
Asha Srinivasan,

Roles Validation

Affiliations Center of Excellence in Molecular Biology and Regenerative Medicine (CEMR) Laboratory (DST-FIST supported center, ICMR collaborating center of excellence – ICMR-CCoE), Department of Biochemistry (DST-FIST supported department), JSS Medical College, JSS Academy of Higher Education & Research (JSS AHER), Mysuru, Karnataka, India, Division of Nanoscience and Technology, School of Life Sciences-Mysuru, JSS Academy of Higher Education & Research (JSS AHER), Mysuru, Karnataka, India
⨯
Rajalakshmi Ramashetty,

Roles Resources, Validation

Affiliation Department of Physiology, JSS Medical College, JSS Academy of Higher Education & Research (JSS AHER), Mysuru, Karnataka, India
⨯
Suma M. Natraj,

Roles Resources, Validation

Affiliation Center of Excellence in Molecular Biology and Regenerative Medicine (CEMR) Laboratory (DST-FIST supported center, ICMR collaborating center of excellence – ICMR-CCoE), Department of Biochemistry (DST-FIST supported department), JSS Medical College, JSS Academy of Higher Education & Research (JSS AHER), Mysuru, Karnataka, India
⨯
SubbaRao V. Madhunapantula

Roles Conceptualization, Funding acquisition, Project administration, Validation, Visualization, Writing – review & editing

* E-mail: mvsstsubbarao@jssuni.edu.in; madhunapantulas@yahoo.com

Affiliations Center of Excellence in Molecular Biology and Regenerative Medicine (CEMR) Laboratory (DST-FIST supported center, ICMR collaborating center of excellence – ICMR-CCoE), Department of Biochemistry (DST-FIST supported department), JSS Medical College, JSS Academy of Higher Education & Research (JSS AHER), Mysuru, Karnataka, India, Leader, Special Interest Group in Cancer Biology and Cancer Stem Cells (SIG-CBCSC), JSS Medical College, JSS Academy of Higher Education & Research (JSS AHER), Mysuru, Karnataka, India

https://orcid.org/0000-0001-9167-9271

⨯

Vitamin D3 reduces the viability of cancer cells in vitro and retard the EAC tumors growth in mice

Vidya G. Bettada,
Chaithanya G. Basavaraju,
Shalini H. Doreswamy,
SubbaRao V. Tulimilli,
Rimshia Naaz,
Siva Dallavalasa,
Paramahans V. Salimath,
Anjali Devi S. Bettadapura,
Asha Srinivasan,
Rajalakshmi Ramashetty

Published: September 8, 2025
https://doi.org/10.1371/journal.pone.0331306

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