Identification and 3D modeling of bioactive peptides from Lactobacillus brevis RAMULAB49 protein hydrolysate with in silico ERK1 phosphorylation inhibition activity targeting diabetic nephropathy

• Reshma Mary Martiz ,

  Contributed equally to this work with: Reshma Mary Martiz, Ramith Ramu

  Roles Investigation, Methodology, Writing – original draft, Formal analysis

  Affiliations Department of Biotechnology and Bioinformatics, JSS Academy of Higher Education & Research, Mysore, Karnataka, India, Department of Microbiology, JSS Academy of Higher Education & Research, Mysore, Karnataka, India

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• Ramith Ramu ,

  Contributed equally to this work with: Reshma Mary Martiz, Ramith Ramu

  Roles Conceptualization, Data curation, Project administration, Resources, Writing – original draft

  * E-mail: ramith.gowda@gmail.com (RR), tangxijun123@126.com (XT), ashwinip@jssuni.edu.in (AP)

  Affiliation Department of Biotechnology and Bioinformatics, JSS Academy of Higher Education & Research, Mysore, Karnataka, India

  https://orcid.org/0000-0003-2776-5815

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• Hemalatha Nambisan,

  Roles Project administration, Resources, Supervision, Investigation, Writing – review & editing

  Affiliation St. Aloysius College of Management and Information Technology, Kotekar, Karnataka, India

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• Ameer Suhail,

  Roles Software, Supervision, Writing – review & editing, Methodology

  Affiliation NeST Digital Private Limited, Kochi, Kerala, India

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• Mohammad Raish,

  Roles Visualization, Writing – review & editing, Validation, Funding acquisition

  Affiliation Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia

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• Shashank M. Patil,

  Roles Formal analysis, Validation, Writing – review & editing

  Affiliation Department of Biotechnology and Bioinformatics, JSS Academy of Higher Education & Research, Mysore, Karnataka, India

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• Ashwini P. ,

  Roles Data curation, Project administration, Supervision, Validation, Writing – review & editing

  * E-mail: ramith.gowda@gmail.com (RR), tangxijun123@126.com (XT), ashwinip@jssuni.edu.in (AP)

  Affiliation Department of Microbiology, JSS Academy of Higher Education & Research, Mysore, Karnataka, India

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• Mahesh B.,

  Roles Investigation, Resources, Supervision, Writing – review & editing

  Affiliation Department of Chemistry, JSS Academy of Technical Education (Affiliated to Visvesvaraya Technological University, Belagavi), Bengaluru, India

  https://orcid.org/0000-0003-4895-7795

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• Maciej Przybyłek,

  Roles Resources, Supervision, Visualization, Writing – review & editing

  Affiliation Department of Physical Chemistry, Pharmacy Faculty, Collegium Medicum of Bydgoszcz, Nicolaus Copernicus University in Toruń, Bydgoszcz, Poland

  https://orcid.org/0000-0002-3399-6129

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• Piotr Bełdowski,

  Roles Methodology, Software, Supervision, Validation, Writing – review & editing

  Affiliation Institute of Computer Science, Kazimierz Wielki University in Bydgoszcz, Bydgoszcz, Poland

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• Alina Sionkowska,

  Roles Funding acquisition, Project administration, Supervision, Visualization, Writing – review & editing

  Affiliation Department of Biomaterials and Cosmetic Chemistry, Faculty of Chemistry, Nicolaus Copernicus University in Toruń, Toruń, Poland

  https://orcid.org/0000-0002-1551-2725

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• Kefeng Li,

  Roles Formal analysis, Software, Supervision, Validation, Writing – review & editing

  Affiliation Faculty of Applied Sciences, Macao Polytechnic University, Macau, China

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• Xijun Tang

  Roles Formal analysis, Supervision, Visualization, Writing – review & editing

  * E-mail: ramith.gowda@gmail.com (RR), tangxijun123@126.com (XT), ashwinip@jssuni.edu.in (AP)

  Affiliation Zhuhai Hospital Affiliated to Faculty of Chinese Medicine, Macau University of Science and Technology, China

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