Secondary metabolites isolated from Fernandoa adenophylla (Wall. ex G.Don) steenis as multitarget inhibitors of cholinesterases for the treatment of Alzheimer’s Disease, followed by molecular docking studies

Maria; Asifullah Khan; Rahaf Ajaj; Abdur Rauf; Marryum; Zafar Ali Shah; Zubair Ahmad; Hassan A. Hemeg; Umer Rashid

doi:10.1371/journal.pone.0331119

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Open Access

Peer-reviewed

Research Article

Secondary metabolites isolated from Fernandoa adenophylla (Wall. ex G.Don) steenis as multitarget inhibitors of cholinesterases for the treatment of Alzheimer’s Disease, followed by molecular docking studies

Maria,

Affiliation Department of Biochemistry, Abdul Wali Khan University, Mardan, Khyber Pakhtunkhwa, Pakistan
⨯
Asifullah Khan ,

Roles Conceptualization, Data curation

* E-mail: mashaljcs@yahoo.com (AR); asifullah111@gmail.com (AK); umerrashid@cuiatd.edu.pk (UR)

Affiliation Department of Biochemistry, Abdul Wali Khan University, Mardan, Khyber Pakhtunkhwa, Pakistan
⨯
Rahaf Ajaj,

Roles Conceptualization, Data curation, Formal analysis, Investigation

Affiliation Department of Environmental and Public Health, College of Health Sciences, Abu Dhabi University, Abu Dhabi, United Arab Emirates

https://orcid.org/0000-0003-3539-2879

⨯
Abdur Rauf ,

Roles Conceptualization, Data curation

* E-mail: mashaljcs@yahoo.com (AR); asifullah111@gmail.com (AK); umerrashid@cuiatd.edu.pk (UR)

Affiliation Department of Chemistry, University of Swabi, Swabi, Anbar, Khyber Pakhtunkhwa, Pakistan

https://orcid.org/0000-0003-2429-5491

⨯
Marryum,

Affiliation Department of Chemistry, COMSATS University Islamabad, Abbottabad Campus, Abbottabad, Pakistan
⨯
Zafar Ali Shah,

Roles Conceptualization, Data curation

Affiliation Department of Agriculture Chemistry and Biochemistry, The University of Agriculture, Peshawar, Khyber Pakhtunkhwa, Pakistan
⨯
Zubair Ahmad,

Roles Conceptualization, Data curation

Affiliation Department of Chemistry, University of Swabi, Swabi, Anbar, Khyber Pakhtunkhwa, Pakistan
⨯
Hassan A. Hemeg,

Roles Conceptualization, Data curation

Affiliation Department of Medical Laboratory Technology, College of Applied Medical Sciences, Taibah University, Al-Medinah Al-Monawara, Madinah, Saudi Arabia
⨯
Umer Rashid

Roles Conceptualization, Data curation

* E-mail: mashaljcs@yahoo.com (AR); asifullah111@gmail.com (AK); umerrashid@cuiatd.edu.pk (UR)

Affiliation Department of Chemistry, COMSATS University Islamabad, Abbottabad Campus, Abbottabad, Pakistan

https://orcid.org/0000-0002-2419-3172

⨯

Secondary metabolites isolated from Fernandoa adenophylla (Wall. ex G.Don) steenis as multitarget inhibitors of cholinesterases for the treatment of Alzheimer’s Disease, followed by molecular docking studies

Maria,
Asifullah Khan,
Rahaf Ajaj,
Abdur Rauf,
Marryum,
Zafar Ali Shah,
Zubair Ahmad,
Hassan A. Hemeg,
Umer Rashid

Published: September 5, 2025
https://doi.org/10.1371/journal.pone.0331119

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