Comparison the impact of IFN-β alone or in combination with vitamin D on critical pathways involved in AML progression

Farzad Nasri; Hassan Jalaeikhoo; Maryam Dadmanesh; Nafiseh Behranvand; Reza Falak; Negin Hosseini Rouzbahan; Yalda Babaei; Khodayar Ghorban

doi:10.1371/journal.pone.0330865

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Open Access

Peer-reviewed

Research Article

Comparison the impact of IFN-β alone or in combination with vitamin D on critical pathways involved in AML progression

Farzad Nasri ,

Contributed equally to this work with: Farzad Nasri, Nafiseh Behranvand

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Software, Writing – original draft, Writing – review & editing

Affiliations Infectious Diseases Research Center, Aja University of Medical Sciences, Tehran, Iran, Department of Immunology, Faculty of Medicine, Aja University of Medical Sciences, Tehran, Iran, Department of Immunology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
⨯
Hassan Jalaeikhoo,

Roles Data curation, Writing – review & editing

Affiliation Department of Hematology and Oncology, Faculty of Medicine, Aja University of Medical Sciences, Tehran, Iran
⨯
Maryam Dadmanesh,

Roles Methodology, Writing – review & editing

Affiliations Infectious Diseases Research Center, Aja University of Medical Sciences, Tehran, Iran, Department of Infectious Diseases, Faculty of Medicine, Aja University of Medical Sciences, Tehran, Iran
⨯
Nafiseh Behranvand ,

Contributed equally to this work with: Farzad Nasri, Nafiseh Behranvand

Roles Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliation Department of Immunology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
⨯
Reza Falak,

Roles Resources, Writing – original draft, Writing – review & editing

Affiliation Department of Immunology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
⨯
Negin Hosseini Rouzbahan,

Roles Writing – review & editing

Affiliations Infectious Diseases Research Center, Aja University of Medical Sciences, Tehran, Iran, Department of Immunology, Faculty of Medicine, Aja University of Medical Sciences, Tehran, Iran
⨯
Yalda Babaei,

Roles Methodology

Affiliation Department of Laboratory Sciences, School of Paramedicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
⨯
Khodayar Ghorban

Roles Conceptualization, Resources, Supervision

* E-mail: kh.ghorban@gmail.com

Affiliations Infectious Diseases Research Center, Aja University of Medical Sciences, Tehran, Iran, Department of Immunology, Faculty of Medicine, Aja University of Medical Sciences, Tehran, Iran

https://orcid.org/0000-0003-3526-5597

⨯

Comparison the impact of IFN-β alone or in combination with vitamin D on critical pathways involved in AML progression

Farzad Nasri,
Hassan Jalaeikhoo,
Maryam Dadmanesh,
Nafiseh Behranvand,
Reza Falak,
Negin Hosseini Rouzbahan,
Yalda Babaei,
Khodayar Ghorban

Published: October 16, 2025
https://doi.org/10.1371/journal.pone.0330865

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Transcription factors
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Acute myeloid leukemia
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Inflammation
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Interferons
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Protein expression
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