Population pharmacokinetic modeling of missed mycophenolate mofetil doses: Impact on exposure and exploration of mitigation strategies

Franck Maizaud; Selim Arraki-Zava; Hamza Sayadi; Yeleen Fromage; Pierre Marquet; Jean-Baptiste Woillard; Caroline Monchaud

doi:10.1371/journal.pone.0330854

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Open Access

Peer-reviewed

Research Article

Population pharmacokinetic modeling of missed mycophenolate mofetil doses: Impact on exposure and exploration of mitigation strategies

Franck Maizaud,

Roles Data curation, Formal analysis, Visualization, Writing – original draft

Affiliation Department of Pharmacology, Toxicology and Pharmacovigilance, CHU Limoges, Limoges, France

https://orcid.org/0009-0002-5103-0827

⨯
Selim Arraki-Zava,

Roles Data curation, Methodology, Software

Affiliation Department of Pharmacology, Toxicology and Pharmacovigilance, CHU Limoges, Limoges, France
⨯
Hamza Sayadi,

Roles Data curation, Methodology, Software

Affiliation Department of Pharmacology, Toxicology and Pharmacovigilance, CHU Limoges, Limoges, France
⨯
Yeleen Fromage,

Roles Data curation, Methodology, Software

Affiliations Department of Pharmacology, Toxicology and Pharmacovigilance, CHU Limoges, Limoges, France, INSERM UMR-1248 “Pharmacology & Transplantation”, Limoges, France

https://orcid.org/0009-0002-3356-557X

⨯
Pierre Marquet,

Roles Methodology, Resources, Supervision

Affiliations Department of Pharmacology, Toxicology and Pharmacovigilance, CHU Limoges, Limoges, France, INSERM UMR-1248 “Pharmacology & Transplantation”, Limoges, France, Fédération Hospitalo-Universitaire “Survival Optimization in Organ Transplantation” (FHU SUPORT), Limoges, France
⨯
Jean-Baptiste Woillard,

Roles Methodology, Software, Supervision, Writing – review & editing

Affiliations Department of Pharmacology, Toxicology and Pharmacovigilance, CHU Limoges, Limoges, France, INSERM UMR-1248 “Pharmacology & Transplantation”, Limoges, France, Fédération Hospitalo-Universitaire “Survival Optimization in Organ Transplantation” (FHU SUPORT), Limoges, France

https://orcid.org/0000-0003-1695-0695

⨯
Caroline Monchaud

Roles Conceptualization, Project administration, Supervision, Writing – review & editing

* E-mail: caroline.monchaud@inserm.fr

Affiliations Department of Pharmacology, Toxicology and Pharmacovigilance, CHU Limoges, Limoges, France, INSERM UMR-1248 “Pharmacology & Transplantation”, Limoges, France, Fédération Hospitalo-Universitaire “Survival Optimization in Organ Transplantation” (FHU SUPORT), Limoges, France

https://orcid.org/0000-0002-9637-5813

⨯

Population pharmacokinetic modeling of missed mycophenolate mofetil doses: Impact on exposure and exploration of mitigation strategies

Franck Maizaud,
Selim Arraki-Zava,
Hamza Sayadi,
Yeleen Fromage,
Pierre Marquet,
Jean-Baptiste Woillard,
Caroline Monchaud

Published: August 28, 2025
https://doi.org/10.1371/journal.pone.0330854

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Adjustment of dosage at steady state
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