Effects of different blood flow rates on filter and circuit life in non-anticoagulation CRRT: Protocol for a three-arm, single-blind randomized controlled trial (the Flow-CRRT Study)

Caihong Liu; Qiongxing Bu; Fang Wang; Wei Wei; Yongxiu Huang; Jinglei Ren; Jay L. Koyner; Ling Zhang; Yuliang Zhao

doi:10.1371/journal.pone.0330845

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Effects of different blood flow rates on filter and circuit life in non-anticoagulation CRRT: Protocol for a three-arm, single-blind randomized controlled trial (the Flow-CRRT Study)

Caihong Liu,

Roles Conceptualization, Formal analysis, Writing – original draft

Affiliation Department of Nephrology, Institute of Kidney Diseases, West China Hospital, Sichuan University, Chengdu, China
⨯
Qiongxing Bu,

Roles Data curation, Methodology

Affiliation Department of Nephrology, Institute of Kidney Diseases, West China Hospital, Sichuan University, Chengdu, China
⨯
Fang Wang,

Roles Data curation

Affiliation Department of Nephrology, West China Hospital of Sichuan University/West China School of Nursing, Sichuan University, Chengdu, China
⨯
Wei Wei,

Roles Methodology

Affiliation Department of Nephrology, Institute of Kidney Diseases, West China Hospital, Sichuan University, Chengdu, China
⨯
Yongxiu Huang,

Roles Investigation

Affiliation Department of Nephrology, Institute of Kidney Diseases, West China Hospital, Sichuan University, Chengdu, China
⨯
Jinglei Ren,

Roles Methodology

Affiliation Department of Nephrology, Institute of Kidney Diseases, West China Hospital, Sichuan University, Chengdu, China
⨯
Jay L. Koyner,

Roles Investigation

Affiliation Department of Medicine, University of Chicago, Chicago, United States of America
⨯
Ling Zhang,

Roles Writing – review & editing

Affiliation Department of Nephrology, Institute of Kidney Diseases, West China Hospital, Sichuan University, Chengdu, China
⨯
Yuliang Zhao

Roles Conceptualization, Writing – review & editing

* E-mail: zhaoyuliang@scu.edu.cn

Affiliation Department of Nephrology, Institute of Kidney Diseases, West China Hospital, Sichuan University, Chengdu, China

https://orcid.org/0000-0001-7660-452X

⨯

Effects of different blood flow rates on filter and circuit life in non-anticoagulation CRRT: Protocol for a three-arm, single-blind randomized controlled trial (the Flow-CRRT Study)

Caihong Liu,
Qiongxing Bu,
Fang Wang,
Wei Wei,
Yongxiu Huang,
Jinglei Ren,
Jay L. Koyner,
Ling Zhang,
Yuliang Zhao

Published: August 22, 2025
https://doi.org/10.1371/journal.pone.0330845

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