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Open Access
Peer-reviewed
Research Article
Low Th2 and high PD1+ TFh cells in blood predict remission after CTLA-4Ig treatment for 48 weeks in early rheumatoid arthritis
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Tilia Selldén ,
Roles Conceptualization, Formal analysis, Methodology, Writing – original draft, Writing – review & editing
* E-mail: tilia.sellden@gu.se
Affiliation Department of Rheumatology and Inflammation Research, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
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Kerstin Andersson,
Roles Formal analysis, Writing – review & editing
Affiliation Department of Rheumatology and Inflammation Research, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
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Inger Gjertsson,
Roles Project administration, Writing – review & editing
Affiliation Department of Rheumatology, Sahlgrenska University Hospital, Gothenburg, Sweden
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Anna-Karin Hultgård Ekwall,
Roles Project administration, Writing – review & editing
Affiliations Department of Rheumatology and Inflammation Research, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, Department of Rheumatology, Sahlgrenska University Hospital, Gothenburg, Sweden
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Kristina Lend,
Roles Project administration, Writing – review & editing
Affiliations Department of Rheumatology and Clinical Immunology, Amsterdam University Medical Center, Amsterdam Rheumatology and Immunology Center, Amsterdam, The Netherlands, Department of Medicine, Rheumatology Unit, Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden
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Merete Lund Hetland,
Roles Project administration, Writing – review & editing
Affiliations Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Centre for Head and Orthopaedics, Rigshospitalet, Copenhagen, Denmark, Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
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Mikkel Østergaard,
Roles Project administration, Writing – review & editing
Affiliations Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Centre for Head and Orthopaedics, Rigshospitalet, Copenhagen, Denmark, Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
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Tillmann Uhlig,
Roles Project administration, Writing – review & editing
Affiliation Center for Treatment of Rheumatic and Musculoskeletal Diseases (REMEDY), Diakonhjemmet Hospital, Oslo, Norway
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Marte Schrumpf Heiberg,
Roles Project administration, Writing – review & editing
Affiliation Center for Treatment of Rheumatic and Musculoskeletal Diseases (REMEDY), Diakonhjemmet Hospital, Oslo, Norway
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Michael T. Nurmohamed,
Roles Project administration, Writing – review & editing
Affiliations Department of Rheumatology and Clinical Immunology, Amsterdam University Medical Center, Amsterdam Rheumatology and Immunology Center, Amsterdam, The Netherlands, Amsterdam Rheumatology and immunology Center, Amsterdam, The Netherlands
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Jon Lampa,
Roles Project administration, Writing – review & editing
Affiliation Department of Medicine, Rheumatology Unit, Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden
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Tuulikki Sokka Isler,
Roles Project administration, Writing – review & editing
Affiliation Jyväskylä Central Hospital, University of Eastern Finland, Jyväskylä, Finland
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Dan Nordström,
Roles Project administration, Writing – review & editing
Affiliation Division of Internal Medicine and Rheumatology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland
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Kim Hørslev-Petersen,
Roles Project administration, Writing – review & editing
Affiliations Department of Rheumatology, Danish Hospital for Rheumatic Diseases, Sønderborg, Denmark, Department of Regional Health Research, University of Southern Denmark, Odense, Denmark
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Bjorn Gudbjornsson,
Roles Project administration, Writing – review & editing
Affiliations Landspitali University Hospital, University of Iceland, Reykjavik, Iceland, Department of Rheumatology, Centre for Rheumatology Research, Reykjavik, Iceland
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Gerdur Gröndal,
Roles Project administration, Writing – review & editing
Affiliations Landspitali University Hospital, University of Iceland, Reykjavik, Iceland, Department of Rheumatology, Centre for Rheumatology Research, Reykjavik, Iceland
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Ronald van Vollenhoven,
Roles Project administration, Writing – review & editing
Affiliations Department of Rheumatology and Clinical Immunology, Amsterdam University Medical Center, Amsterdam Rheumatology and Immunology Center, Amsterdam, The Netherlands, Department of Medicine, Rheumatology Unit, Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden
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Cristina Maglio,
Roles Formal analysis, Writing – review & editing
Affiliations Department of Rheumatology and Inflammation Research, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, Department of Rheumatology, Sahlgrenska University Hospital, Gothenburg, Sweden
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Anna-Carin Lundell,
Roles Conceptualization, Formal analysis, Writing – original draft, Writing – review & editing
Affiliation Department of Rheumatology and Inflammation Research, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
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Anna Rudin
Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Project administration, Writing – original draft, Writing – review & editing
Affiliations Department of Rheumatology and Inflammation Research, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, Department of Rheumatology, Sahlgrenska University Hospital, Gothenburg, Sweden
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Low Th2 and high PD1+ TFh cells in blood predict remission after CTLA-4Ig treatment for 48 weeks in early rheumatoid arthritis
- Tilia Selldén,
- Kerstin Andersson,
- Inger Gjertsson,
- Anna-Karin Hultgård Ekwall,
- Kristina Lend,
- Merete Lund Hetland,
- Mikkel Østergaard,
- Tillmann Uhlig,
- Marte Schrumpf Heiberg,
- Michael T. Nurmohamed
- Published: August 28, 2025
- https://doi.org/10.1371/journal.pone.0330823