Investigating the Trichosanthis Pericarpium - Trichosanthis Radix herbal pair’s role in alleviating COPD through gut microbiota function, metabolomics analysis and cell validation experiment

• Yushan Zhao,

  Roles Data curation, Formal analysis, Validation, Writing – original draft

  Affiliation Jiangsu Provincial Key Laboratory of Functional Substances in Traditional Chinese Medicine Formulae and Innovative Drug Discovery, Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing, China

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• Xiaoying Tan,

  Roles Investigation, Methodology, Validation

  Affiliation Jiangsu Provincial Key Laboratory of Functional Substances in Traditional Chinese Medicine Formulae and Innovative Drug Discovery, Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing, China

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• Tian Wang,

  Roles Investigation, Methodology, Validation

  Affiliation Jiangsu Provincial Key Laboratory of Functional Substances in Traditional Chinese Medicine Formulae and Innovative Drug Discovery, Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing, China

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• Yuxuan Yuan,

  Roles Data curation, Investigation, Methodology

  Affiliation Jiangsu Provincial Key Laboratory of Functional Substances in Traditional Chinese Medicine Formulae and Innovative Drug Discovery, Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing, China

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• Kelei Su,

  Roles Investigation, Resources

  Affiliation Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Third Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, China

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• Erxin Shang,

  Roles Methodology, Software, Validation

  Affiliation Jiangsu Provincial Key Laboratory of Functional Substances in Traditional Chinese Medicine Formulae and Innovative Drug Discovery, Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing, China

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• Qingling Xiao,

  Roles Supervision, Visualization

  Affiliation Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Third Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, China

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• Sheng Guo,

  Roles Investigation, Methodology, Resources

  Affiliation Jiangsu Provincial Key Laboratory of Functional Substances in Traditional Chinese Medicine Formulae and Innovative Drug Discovery, Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing, China

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• Shulan Su,

  Roles Investigation, Methodology, Resources

  Affiliation Jiangsu Provincial Key Laboratory of Functional Substances in Traditional Chinese Medicine Formulae and Innovative Drug Discovery, Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing, China

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• Huangqin Zhang ,

  Roles Data curation, Formal analysis, Funding acquisition, Validation

  * E-mail: liupei@njucm.edu.cn (P. Liu); dja@njucm.edu.cn (J.A. Duan); 520002@njucm.edu.cn (H.Q. Zhang)

  Affiliation State Key Laboratory of Technologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture, Nanjing University of Chinese Medicine, Nanjing, China

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• Jin-ao Duan ,

  Roles Funding acquisition, Project administration, Supervision

  * E-mail: liupei@njucm.edu.cn (P. Liu); dja@njucm.edu.cn (J.A. Duan); 520002@njucm.edu.cn (H.Q. Zhang)

  Affiliation Jiangsu Provincial Key Laboratory of Functional Substances in Traditional Chinese Medicine Formulae and Innovative Drug Discovery, Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing, China

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• Pei Liu

  Roles Funding acquisition, Methodology, Project administration, Writing – review & editing

  * E-mail: liupei@njucm.edu.cn (P. Liu); dja@njucm.edu.cn (J.A. Duan); 520002@njucm.edu.cn (H.Q. Zhang)

  Affiliation Jiangsu Provincial Key Laboratory of Functional Substances in Traditional Chinese Medicine Formulae and Innovative Drug Discovery, Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing, China

  https://orcid.org/0000-0003-2664-0551

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