Piezo1 regulates autophagy in HT22 hippocampal neurons through the Ca2+/Calpain and Calcineurin/TFEB signaling pathways

Yatong Wu; Yan Lu; Hao Zhang; Suhe Dong; Ziqing Zhang; Sinian Wang; Fengsheng Li; Shimin Yin

doi:10.1371/journal.pone.0330282

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Open Access

Peer-reviewed

Research Article

Piezo1 regulates autophagy in HT22 hippocampal neurons through the Ca²⁺/Calpain and Calcineurin/TFEB signaling pathways

Yatong Wu ,

Roles Formal analysis, Methodology, Software, Writing – original draft

¶☯ Yatong Wu and Yan Lu contributed equally to this work and should be considered co-first authors.

Affiliation The Postgraduate Training Base of Jinzhou Medical University (The PLA Rocket Force Characteristic Medical Center), Beijing, China
⨯
Yan Lu ,

Roles Conceptualization, Writing – review & editing

¶☯ Yatong Wu and Yan Lu contributed equally to this work and should be considered co-first authors.

Affiliation Department of Neurology, The PLA Rocket Force Characteristic Medical Center, Beijing, China
⨯
Hao Zhang,

Roles Conceptualization, Validation, Writing – review & editing

Affiliation Department of Anesthesiology, The PLA Rocket Force Characteristic Medical Center, Beijing, China

https://orcid.org/0000-0001-5624-9217

⨯
Suhe Dong,

Roles Formal analysis, Software

Affiliation Department of Nuclear Radiation Injury and Monitoring, The PLA Rocket Force Characteristic Medical Center, Beijing, China
⨯
Ziqing Zhang,

Roles Formal analysis, Visualization

Affiliation The Postgraduate Training Base of Jinzhou Medical University (The PLA Rocket Force Characteristic Medical Center), Beijing, China

https://orcid.org/0000-0002-6230-235X

⨯
Sinian Wang,

Roles Formal analysis

Affiliation Department of Nuclear Radiation Injury and Monitoring, The PLA Rocket Force Characteristic Medical Center, Beijing, China
⨯
Fengsheng Li ,

Roles Resources

* E-mail: lifs0624@163.com (FSL); yin_shi_min@126.com (SMY)

Affiliation Department of Nuclear Radiation Injury and Monitoring, The PLA Rocket Force Characteristic Medical Center, Beijing, China
⨯
Shimin Yin

Roles Conceptualization, Supervision

* E-mail: lifs0624@163.com (FSL); yin_shi_min@126.com (SMY)

Affiliation Department of Neurology, The PLA Rocket Force Characteristic Medical Center, Beijing, China

https://orcid.org/0000-0002-3824-4655

⨯

Piezo1 regulates autophagy in HT22 hippocampal neurons through the Ca²⁺/Calpain and Calcineurin/TFEB signaling pathways

Yatong Wu,
Yan Lu,
Hao Zhang,
Suhe Dong,
Ziqing Zhang,
Sinian Wang,
Fengsheng Li,
Shimin Yin

Published: August 26, 2025
https://doi.org/10.1371/journal.pone.0330282

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Autophagic cell death
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Neurons
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Calcineurin signaling cascade
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Small interfering RNA
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Calcium signaling
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Apoptosis
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Vacuoles
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Hippocampus
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