ACE1 does not influence cerebral Aβ degradation or amyloid plaque accumulation in 5XFAD mice

Sohee Jeon; Alia O. Alia; Jelena Popovic; Robert Vassar; Leah K. Cuddy

doi:10.1371/journal.pone.0330193

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Open Access

Peer-reviewed

Research Article

ACE1 does not influence cerebral Aβ degradation or amyloid plaque accumulation in 5XFAD mice

Sohee Jeon,

Roles Conceptualization, Formal analysis, Investigation, Visualization, Writing – original draft, Writing – review & editing

Affiliation The Ken and Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America
⨯
Alia O. Alia,

Roles Conceptualization, Formal analysis, Investigation

Affiliation The Ken and Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America

https://orcid.org/0009-0006-1346-7437

⨯
Jelena Popovic,

Roles Investigation

Affiliation The Ken and Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America
⨯
Robert Vassar ,

Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – review & editing

* E-mail: r-vassar@northwestern.edu (RV); leah.cuddy@northwestern.edu (LKC)

Affiliations The Ken and Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America, Mesulam Center for Cognitive Neurology and Alzheimer’s Disease, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America
⨯
Leah K. Cuddy

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Supervision, Validation, Visualization, Writing – review & editing

* E-mail: r-vassar@northwestern.edu (RV); leah.cuddy@northwestern.edu (LKC)

Affiliation The Ken and Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America

https://orcid.org/0000-0002-6764-3065

⨯

ACE1 does not influence cerebral Aβ degradation or amyloid plaque accumulation in 5XFAD mice

Sohee Jeon,
Alia O. Alia,
Jelena Popovic,
Robert Vassar,
Leah K. Cuddy

Published: September 15, 2025
https://doi.org/10.1371/journal.pone.0330193

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