Study on the alteration of gut microbiota in ovariectomized rats and the impact of estrogen intervention over a 3-month period

XinDong Lei; TingTing Cheng; Han Dong; JieYing Xia; Yang Hong; GuoQiang Cheng; YongJin Wang; TieZhu Chen

doi:10.1371/journal.pone.0330108

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Open Access

Peer-reviewed

Research Article

Study on the alteration of gut microbiota in ovariectomized rats and the impact of estrogen intervention over a 3-month period

XinDong Lei ,

Contributed equally to this work with: XinDong Lei, TingTing Cheng

Roles Conceptualization, Data curation, Formal analysis, Methodology, Project administration, Writing – original draft, Writing – review & editing

Affiliation Animal Experiment Center, Sichuan Academy of Chinese Medicine Sciences, ChengDu, SiChuan, China

https://orcid.org/0009-0001-7629-6763

⨯
TingTing Cheng ,

Contributed equally to this work with: XinDong Lei, TingTing Cheng

Roles Conceptualization, Data curation, Formal analysis, Project administration, Writing – review & editing

Affiliation Animal Experiment Center, Sichuan Academy of Chinese Medicine Sciences, ChengDu, SiChuan, China
⨯
Han Dong,

Roles Resources, Software, Supervision, Validation

Affiliation Animal Experiment Center, Sichuan Academy of Chinese Medicine Sciences, ChengDu, SiChuan, China
⨯
JieYing Xia,

Roles Methodology, Project administration, Resources, Visualization

Affiliation Animal Experiment Center, Sichuan Academy of Chinese Medicine Sciences, ChengDu, SiChuan, China
⨯
Yang Hong,

Roles Investigation, Methodology, Writing – review & editing

Affiliation Animal Experiment Center, Sichuan Academy of Chinese Medicine Sciences, ChengDu, SiChuan, China
⨯
GuoQiang Cheng,

Roles Project administration, Software, Writing – review & editing

Affiliation Animal Experiment Center, Sichuan Academy of Chinese Medicine Sciences, ChengDu, SiChuan, China
⨯
YongJin Wang,

Roles Supervision

Affiliation Animal Experiment Center, Sichuan Academy of Chinese Medicine Sciences, ChengDu, SiChuan, China
⨯
TieZhu Chen

Roles Funding acquisition, Supervision, Writing – review & editing

* E-mail: cctzcd@126.com

Affiliation Animal Experiment Center, Sichuan Academy of Chinese Medicine Sciences, ChengDu, SiChuan, China

https://orcid.org/0000-0002-6294-6630

⨯

Study on the alteration of gut microbiota in ovariectomized rats and the impact of estrogen intervention over a 3-month period

XinDong Lei,
TingTing Cheng,
Han Dong,
JieYing Xia,
Yang Hong,
GuoQiang Cheng,
YongJin Wang,
TieZhu Chen

Published: September 4, 2025
https://doi.org/10.1371/journal.pone.0330108

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Estrogens
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Ovariectomy
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Gut bacteria
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Gastrointestinal tract
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