An unexpected role of CLASP1 in radiation response and S-phase regulation of head and neck cancer cells

Reinout H. de Roest; Marijke Buijze; Myrthe Veth; Klaas de Lint; Govind Pai; Martin A. Rooimans; Rob M.F. Wolthuis; Arjen Brink; Jos B. Poell; Ruud H. Brakenhoff

doi:10.1371/journal.pone.0329731

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Open Access

Peer-reviewed

Research Article

An unexpected role of CLASP1 in radiation response and S-phase regulation of head and neck cancer cells

Reinout H. de Roest ,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – original draft

* E-mail: r.deroest@amsterdamumc.nl (RHR), rh.brakenhoff@amsterdamumc.nl (RHB)

Affiliations Amsterdam UMC location VUmc Amsterdam, Otolaryngology/Head and Neck Surgery, Head and Neck Cancer Biology and Immunology laboratory, Amsterdam, The Netherlands, Cancer Center Amsterdam, Cancer Biology and Immunology, Amsterdam, The Netherlands

https://orcid.org/0000-0003-3221-7194

⨯
Marijke Buijze,

Roles Investigation, Methodology

Affiliations Amsterdam UMC location VUmc Amsterdam, Otolaryngology/Head and Neck Surgery, Head and Neck Cancer Biology and Immunology laboratory, Amsterdam, The Netherlands, Cancer Center Amsterdam, Cancer Biology and Immunology, Amsterdam, The Netherlands
⨯
Myrthe Veth,

Roles Investigation, Methodology

Affiliations Amsterdam UMC location VUmc Amsterdam, Otolaryngology/Head and Neck Surgery, Head and Neck Cancer Biology and Immunology laboratory, Amsterdam, The Netherlands, Cancer Center Amsterdam, Cancer Biology and Immunology, Amsterdam, The Netherlands
⨯
Klaas de Lint,

Roles Investigation, Methodology, Resources, Writing – review & editing

Affiliations Cancer Center Amsterdam, Cancer Biology and Immunology, Amsterdam, The Netherlands, Amsterdam UMC location VUmc Amsterdam, Human Genetics, Oncogenetics laboratory, Amsterdam, The Netherlands
⨯
Govind Pai,

Roles Investigation, Methodology, Writing – review & editing

Affiliations Cancer Center Amsterdam, Cancer Biology and Immunology, Amsterdam, The Netherlands, Amsterdam UMC location VUmc Amsterdam, Human Genetics, Oncogenetics laboratory, Amsterdam, The Netherlands
⨯
Martin A. Rooimans,

Roles Investigation, Methodology

Affiliations Cancer Center Amsterdam, Cancer Biology and Immunology, Amsterdam, The Netherlands, Amsterdam UMC location VUmc Amsterdam, Human Genetics, Oncogenetics laboratory, Amsterdam, The Netherlands
⨯
Rob M.F. Wolthuis,

Roles Methodology, Writing – review & editing

Affiliations Cancer Center Amsterdam, Cancer Biology and Immunology, Amsterdam, The Netherlands, Amsterdam UMC location VUmc Amsterdam, Human Genetics, Oncogenetics laboratory, Amsterdam, The Netherlands
⨯
Arjen Brink,

Roles Formal analysis, Investigation, Writing – review & editing

Affiliations Amsterdam UMC location VUmc Amsterdam, Otolaryngology/Head and Neck Surgery, Head and Neck Cancer Biology and Immunology laboratory, Amsterdam, The Netherlands, Cancer Center Amsterdam, Cancer Biology and Immunology, Amsterdam, The Netherlands
⨯
Jos B. Poell,

Roles Formal analysis, Methodology, Writing – review & editing

Affiliations Amsterdam UMC location VUmc Amsterdam, Otolaryngology/Head and Neck Surgery, Head and Neck Cancer Biology and Immunology laboratory, Amsterdam, The Netherlands, Cancer Center Amsterdam, Cancer Biology and Immunology, Amsterdam, The Netherlands

https://orcid.org/0000-0003-1776-3779

⨯
Ruud H. Brakenhoff

Roles Conceptualization, Methodology, Supervision, Writing – review & editing

* E-mail: r.deroest@amsterdamumc.nl (RHR), rh.brakenhoff@amsterdamumc.nl (RHB)

Affiliations Amsterdam UMC location VUmc Amsterdam, Otolaryngology/Head and Neck Surgery, Head and Neck Cancer Biology and Immunology laboratory, Amsterdam, The Netherlands, Cancer Center Amsterdam, Cancer Biology and Immunology, Amsterdam, The Netherlands
⨯

An unexpected role of CLASP1 in radiation response and S-phase regulation of head and neck cancer cells

Reinout H. de Roest,
Marijke Buijze,
Myrthe Veth,
Klaas de Lint,
Govind Pai,
Martin A. Rooimans,
Rob M.F. Wolthuis,
Arjen Brink,
Jos B. Poell,
Ruud H. Brakenhoff

Published: August 6, 2025
https://doi.org/10.1371/journal.pone.0329731

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DNA damage
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Cloning
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Ionizing radiation
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