ITIH2 in colorectal cancer metastasis: Weighted Gene Co-expression Network Analysis-guided functional validation

Xin-Feng Zhang; Xiao-Li Zhang; Hai-Wen Xu; Ya-Hui Lin; Yan Tian; Cheng Chen; Huayou Luo

doi:10.1371/journal.pone.0329719

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Open Access

Peer-reviewed

Research Article

ITIH2 in colorectal cancer metastasis: Weighted Gene Co-expression Network Analysis-guided functional validation

Xin-Feng Zhang,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Writing – original draft, Writing – review & editing

Affiliation Department of Gastrointestinal and Hernia Surgery, The First Affiliated Hospital of Kunming Medical University, China
⨯
Xiao-Li Zhang,

Roles Data curation, Methodology, Writing – original draft, Writing – review & editing

Affiliation Department of Gastrointestinal and Hernia Surgery, The First Affiliated Hospital of Kunming Medical University, China
⨯
Hai-Wen Xu,

Roles Conceptualization, Investigation, Writing – original draft, Writing – review & editing

Affiliation Trauma Center, The First Affiliated Hospital of Kunming Medical University, China
⨯
Ya-Hui Lin,

Roles Formal analysis, Investigation, Writing – original draft

Affiliation Department of Gastrointestinal and Hernia Surgery, The First Affiliated Hospital of Kunming Medical University, China
⨯
Yan Tian ,

Roles Conceptualization, Investigation, Resources, Writing – original draft, Writing – review & editing

* E-mail: km-lhy@qq.com (HYL); 905790434@qq.com (YT); ccRachel211@163.com (CC)

Affiliation Department of Gastrointestinal and Hernia Surgery, The First Affiliated Hospital of Kunming Medical University, China
⨯
Cheng Chen ,

Roles Formal analysis, Funding acquisition, Resources, Writing – original draft, Writing – review & editing

* E-mail: km-lhy@qq.com (HYL); 905790434@qq.com (YT); ccRachel211@163.com (CC)

Affiliation Department of Gastrointestinal and Hernia Surgery, The First Affiliated Hospital of Kunming Medical University, China
⨯
Huayou Luo

Roles Data curation, Formal analysis, Funding acquisition, Writing – original draft, Writing – review & editing

* E-mail: km-lhy@qq.com (HYL); 905790434@qq.com (YT); ccRachel211@163.com (CC)

Affiliation Department of Gastrointestinal and Hernia Surgery, The First Affiliated Hospital of Kunming Medical University, China

https://orcid.org/0009-0001-7391-4335

⨯

ITIH2 in colorectal cancer metastasis: Weighted Gene Co-expression Network Analysis-guided functional validation

Xin-Feng Zhang,
Xiao-Li Zhang,
Hai-Wen Xu,
Ya-Hui Lin,
Yan Tian,
Cheng Chen,
Huayou Luo

Published: February 5, 2026
https://doi.org/10.1371/journal.pone.0329719

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Colorectal cancer
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Metastasis
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Lung and intrathoracic tumors
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Hepatocellular carcinoma
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Gene expression
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Transcriptome analysis
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Cancers and neoplasms
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Renal cancer
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