Immune cells play a critical role in cytokine- and endotoxin-mediated endothelial permeability

Patricia Gogesch; Samira Ortega Iannazzo; Nicole Rupp; Joachim Rom; Markus Kreuz; Kristin Reiche; Martina Anzaghe; Zoe Waibler; on behalf of the imSAVAR Consortium

doi:10.1371/journal.pone.0329700

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Open Access

Peer-reviewed

Research Article

Immune cells play a critical role in cytokine- and endotoxin-mediated endothelial permeability

Patricia Gogesch ,

Contributed equally to this work with: Patricia Gogesch, Samira Ortega Iannazzo

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

Affiliation Division of Immunology, Paul-Ehrlich-Institut, Langen, Germany

https://orcid.org/0000-0003-0025-0782

⨯
Samira Ortega Iannazzo ,

Contributed equally to this work with: Patricia Gogesch, Samira Ortega Iannazzo

Roles Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

Affiliation Division of Immunology, Paul-Ehrlich-Institut, Langen, Germany
⨯
Nicole Rupp,

Roles Data curation, Formal analysis, Methodology, Visualization, Writing – review & editing

Affiliation Division of Immunology, Paul-Ehrlich-Institut, Langen, Germany
⨯
Joachim Rom,

Roles Resources

Affiliation Department of Gynecology, Varisano Klinikum sFrankfurt Höchst, Frankfurt, Germany

https://orcid.org/0000-0002-9738-5503

⨯
Markus Kreuz,

Roles Formal analysis, Visualization, Writing – review & editing

Affiliation Department of Diagnostics, Fraunhofer Institute for Cell Therapy and Immunology IZI, Leipzig, Germany
⨯
Kristin Reiche,

Roles Formal analysis, Resources

Affiliation Department of Diagnostics, Fraunhofer Institute for Cell Therapy and Immunology IZI, Leipzig, Germany
⨯
Martina Anzaghe,

Roles Investigation, Supervision, Writing – review & editing

Affiliation Division of Immunology, Paul-Ehrlich-Institut, Langen, Germany
⨯
Zoe Waibler ,

Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – review & editing

* E-mail: zoe.waibler@pei.de

Affiliation Division of Immunology, Paul-Ehrlich-Institut, Langen, Germany

https://orcid.org/0000-0001-5758-2652

⨯
on behalf of the imSAVAR Consortium

Affiliation Division of Immunology, Paul-Ehrlich-Institut, Langen, Germany
⨯

Immune cells play a critical role in cytokine- and endotoxin-mediated endothelial permeability

Patricia Gogesch,
Samira Ortega Iannazzo,
Nicole Rupp,
Joachim Rom,
Markus Kreuz,
Kristin Reiche,
Martina Anzaghe,
Zoe Waibler,
on behalf of the imSAVAR Consortium

Published: August 14, 2025
https://doi.org/10.1371/journal.pone.0329700

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Cytokines
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Permeability
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Immune cells
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Thrombin
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Vascular permeability
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Cytokine therapy
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Flow cytometry
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