Mechanism of Astragaloside-Brucea javanica oil nanoemulsion against oral squamous cell carcinoma through CDK1/MTFR2: Network pharmacology, bioinformatics, and experimental studies

• Yihan Lai ,

  Roles Conceptualization, Formal analysis, Methodology, Writing – original draft

  ¶‡ Yihan Lai and Runqiang Liu are co-first authors.

  Affiliation Jiangxi University of Chinese Medicine, Nanchang, Jiangxi Province, China

  https://orcid.org/0009-0003-3656-0923

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• Runqiang Liu ,

  Roles Investigation, Methodology, Software

  ¶‡ Yihan Lai and Runqiang Liu are co-first authors.

  Affiliation School of Stomatology, Nanchang University, Nanchang, Jiangxi Province, China

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• Huajie Shao,

  Roles Investigation

  Affiliation Department of Oral and Maxillofacial Surgery, Key Laboratory of Oral Diseases of Traditional Chinese Medicine, Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang, Jiangxi Province, China

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• Juan Zhan,

  Roles Investigation

  Affiliation Jiangxi University of Chinese Medicine, Nanchang, Jiangxi Province, China

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• Yujie Ma,

  Roles Investigation

  Affiliation School of Stomatology, Nanchang University, Nanchang, Jiangxi Province, China

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• Lanfei Zhou,

  Roles Data curation

  Affiliation Department of Otorhinolaryngology, Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang, Jiangxi Province, China

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• Zhichao Wan,

  Roles Data curation

  Affiliations Jiangxi University of Chinese Medicine, Nanchang, Jiangxi Province, China, Department of Otorhinolaryngology, Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang, Jiangxi Province, China

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• Sicheng Li,

  Roles Software

  Affiliation School of Stomatology, Nanchang University, Nanchang, Jiangxi Province, China

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• Wei Wang,

  Roles Methodology, Visualization

  Affiliation Department of Oral and Maxillofacial Surgery, Key Laboratory of Oral Diseases of Traditional Chinese Medicine, Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang, Jiangxi Province, China

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• Lin Jiang,

  Roles Supervision

  Affiliation Department of Oral and Maxillofacial Surgery, Key Laboratory of Oral Diseases of Traditional Chinese Medicine, Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang, Jiangxi Province, China

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• Yisen Shao

  Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

  * E-mail: shaoyisen@jxutcm.edu.cn

  Affiliation Department of Oral and Maxillofacial Surgery, Key Laboratory of Oral Diseases of Traditional Chinese Medicine, Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang, Jiangxi Province, China

  https://orcid.org/0009-0001-4847-7938

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