Ghrelin improves small intestinal barrier damage in sepsis by promoting miR-143/ATG2B-mediated autophagy

Jingquan Liu; Kai Shi; Hanhui Cai; Zihao Zheng; Bin Fan; Xianghong Yang; Ziqiang Shao

doi:10.1371/journal.pone.0329488

Loading metrics

Open Access

Peer-reviewed

Research Article

Ghrelin improves small intestinal barrier damage in sepsis by promoting miR-143/ATG2B-mediated autophagy

Jingquan Liu,

Roles Conceptualization, Funding acquisition, Investigation, Project administration, Writing – original draft

Affiliation Emergency and Critical Care Center, Intensive Care Unit, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China
⨯
Kai Shi,

Roles Data curation, Funding acquisition, Investigation, Methodology

Affiliation Department of Respiratory Medicine, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang, China
⨯
Hanhui Cai,

Roles Formal analysis, Investigation, Methodology, Visualization

Affiliation Emergency and Critical Care Center, Intensive Care Unit, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China
⨯
Zihao Zheng,

Roles Data curation, Formal analysis, Validation

Affiliation Emergency and Critical Care Center, Intensive Care Unit, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China
⨯
Bin Fan,

Roles Funding acquisition, Investigation, Visualization

Affiliation Emergency and Critical Care Center, Intensive Care Unit, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China
⨯
Xianghong Yang ,

Roles Conceptualization, Project administration, Supervision, Writing – review & editing

* E-mail: szqdoctor@163.com (ZS), jyy623@163.com (XY)

Affiliation Emergency and Critical Care Center, Intensive Care Unit, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China
⨯
Ziqiang Shao

Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

* E-mail: szqdoctor@163.com (ZS), jyy623@163.com (XY)

Affiliation Emergency and Critical Care Center, Intensive Care Unit, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China
⨯

Ghrelin improves small intestinal barrier damage in sepsis by promoting miR-143/ATG2B-mediated autophagy

Jingquan Liu,
Kai Shi,
Hanhui Cai,
Zihao Zheng,
Bin Fan,
Xianghong Yang,
Ziqiang Shao

Published: August 7, 2025
https://doi.org/10.1371/journal.pone.0329488

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Gastrointestinal tract
Is the Subject Area "Gastrointestinal tract" applicable to this article?

Thanks for your feedback.
Autophagic cell death
Is the Subject Area "Autophagic cell death" applicable to this article?

Thanks for your feedback.
Sepsis
Is the Subject Area "Sepsis" applicable to this article?

Thanks for your feedback.
Small intestine
Is the Subject Area "Small intestine" applicable to this article?

Thanks for your feedback.
Growth hormone
Is the Subject Area "Growth hormone" applicable to this article?

Thanks for your feedback.
Surgical and invasive medical procedures
Is the Subject Area "Surgical and invasive medical procedures" applicable to this article?

Thanks for your feedback.
Transfection
Is the Subject Area "Transfection" applicable to this article?

Thanks for your feedback.
Protein expression
Is the Subject Area "Protein expression" applicable to this article?

Thanks for your feedback.