Cerebrospinal fluid haptoglobin levels and outcome after aneurysmal subarachnoid haemorrhage: Evidence from Mendelian randomization

Gbenga A. Kayode; Loukas Zagkos; Godspower Oboli; Sonya Abraham; Gregory Kato; Quazi Ataher; Evangelia Farmakioti; Lothar Tremmel; Stephen Burgess

doi:10.1371/journal.pone.0329287

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Open Access

Peer-reviewed

Research Article

Cerebrospinal fluid haptoglobin levels and outcome after aneurysmal subarachnoid haemorrhage: Evidence from Mendelian randomization

Gbenga A. Kayode ,

Contributed equally to this work with: Gbenga A. Kayode, Loukas Zagkos

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Writing – review & editing

Affiliation CSL BEHRING L.L.C., King of Prussia, Pennsylvania, United States of America
⨯
Loukas Zagkos ,

Contributed equally to this work with: Gbenga A. Kayode, Loukas Zagkos

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Lane Clark & Peacock LLP, London, United Kingdom

https://orcid.org/0000-0002-7700-8102

⨯
Godspower Oboli,

Roles Data curation, Formal analysis, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Lane Clark & Peacock LLP, London, United Kingdom
⨯
Sonya Abraham,

Roles Writing – review & editing

Affiliation CSL BEHRING L.L.C., King of Prussia, Pennsylvania, United States of America
⨯
Gregory Kato,

Roles Writing – review & editing

Affiliation CSL BEHRING L.L.C., King of Prussia, Pennsylvania, United States of America

https://orcid.org/0000-0003-4465-3217

⨯
Quazi Ataher,

Roles Writing – review & editing

Affiliation CSL BEHRING L.L.C., King of Prussia, Pennsylvania, United States of America
⨯
Evangelia Farmakioti,

Roles Writing – review & editing

Affiliation CSL Innovation GmBH, Marburg, Germany
⨯
Lothar Tremmel,

Roles Writing – review & editing

Affiliation CSL BEHRING L.L.C., King of Prussia, Pennsylvania, United States of America
⨯
Stephen Burgess

Roles Conceptualization, Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing

* E-mail: sb452@medschl.cam.ac.uk

Affiliation MRC Biostatistics Unit, School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom
⨯

Cerebrospinal fluid haptoglobin levels and outcome after aneurysmal subarachnoid haemorrhage: Evidence from Mendelian randomization

Gbenga A. Kayode,
Loukas Zagkos,
Godspower Oboli,
Sonya Abraham,
Gregory Kato,
Quazi Ataher,
Evangelia Farmakioti,
Lothar Tremmel,
Stephen Burgess

Published: August 5, 2025
https://doi.org/10.1371/journal.pone.0329287

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Haptoglobins
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Cerebrospinal fluid
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Genetics
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Hemorrhagic stroke
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