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Open Access
Peer-reviewed
Research Article
Inflammatory cytokines promote interferon regulatory factor (IRF) transcriptional activity in human pulmonary epithelial cells through the induction of IRF1 by nuclear factor-κB
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Amandah Necker-Brown,
Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing
Affiliation Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada
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Mahmoud M. Mostafa,
Roles Formal analysis, Visualization, Writing – review & editing
Affiliation Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada
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Andrei Georgescu,
Roles Investigation, Writing – review & editing
Affiliation Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada
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Andrew J. Thorne,
Roles Investigation, Writing – review & editing
Affiliation Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada
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Priyanka Chandramohan,
Roles Investigation
Affiliation Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada
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Cora Kooi,
Roles Investigation, Writing – review & editing
Affiliations Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada, Department of Medicine, Lung Health Research Group, Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
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Keerthana Kalyanaraman,
Roles Investigation, Writing – review & editing
Affiliation Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada
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Alex Gao,
Roles Investigation
Affiliation Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada
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Akanksha Bansal,
Roles Investigation
Affiliation Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada
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Sarah K. Sasse,
Roles Data curation, Formal analysis, Writing – review & editing
Affiliation Department of Medicine, National Jewish Health, Denver, Colorado, United States of America
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Anthony N. Gerber,
Roles Formal analysis, Resources, Supervision
Affiliations Department of Medicine, National Jewish Health, Denver, Colorado, United States of America, Department of Immunology and Genomic Medicine, National Jewish Health, Denver, Colorado, United States of America
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Richard Leigh,
Roles Resources, Supervision, Writing – review & editing
Affiliation Department of Medicine, Lung Health Research Group, Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
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Robert Newton
Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing
* E-mail: rnewton@ucalgary.ca
Affiliation Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada
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Inflammatory cytokines promote interferon regulatory factor (IRF) transcriptional activity in human pulmonary epithelial cells through the induction of IRF1 by nuclear factor-κB
- Amandah Necker-Brown,
- Mahmoud M. Mostafa,
- Andrei Georgescu,
- Andrew J. Thorne,
- Priyanka Chandramohan,
- Cora Kooi,
- Keerthana Kalyanaraman,
- Alex Gao,
- Akanksha Bansal,
- Sarah K. Sasse
- Published: December 8, 2025
- https://doi.org/10.1371/journal.pone.0329244