Liver-specific glucagon dysfunction promotes PP-cell hyperplasia and formation of glucagon and PP double-positive cells

• Yuko Nakagawa,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Laboratory of Developmental Biology and Metabolism, Institute for Molecular and Cellular Regulation (IMCR), Gunma University, Maebashi, Japan

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• Takuro Horii,

  Roles Investigation, Resources

  Affiliation Laboratory of Genome Science, Biosignal Genome Resource Center, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan

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• Ayako Fukunaka,

  Roles Conceptualization

  Affiliation Laboratory of Developmental Biology and Metabolism, Institute for Molecular and Cellular Regulation (IMCR), Gunma University, Maebashi, Japan

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• Takashi Sato,

  Roles Conceptualization

  Affiliation Laboratory of Developmental Biology and Metabolism, Institute for Molecular and Cellular Regulation (IMCR), Gunma University, Maebashi, Japan

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• Zhehao Zhang,

  Roles Investigation

  Affiliation Laboratory of Developmental Biology and Metabolism, Institute for Molecular and Cellular Regulation (IMCR), Gunma University, Maebashi, Japan

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• Masaki Kobayashi,

  Roles Resources

  Affiliation Metabolic Signal Research Center, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan

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• Tadahiro Kitamura,

  Roles Resources

  Affiliation Metabolic Signal Research Center, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan

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• Yoshitaka Hayashi,

  Roles Resources

  Affiliation Department of Endocrinology, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan

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• Takashi Nishimura,

  Roles Investigation

  Affiliation Laboratory of Metabolic Regulation and Genetics, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan

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• Izuho Hatada,

  Roles Resources

  Affiliation Laboratory of Genome Science, Biosignal Genome Resource Center, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan

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• Yoshio Fujitani

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: fujitani@gunma-u.ac.jp

  Affiliation Laboratory of Developmental Biology and Metabolism, Institute for Molecular and Cellular Regulation (IMCR), Gunma University, Maebashi, Japan

  https://orcid.org/0000-0003-0196-4736

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