Mediating role of inflammatory markers in the relationship between cotinine levels and total bone mineral density

Lei Huang; Xianghong Wang; Xianxu Zhang; Shicheng Li; Xin Liu; Zhong Ma; Bin Qian; Changlin Zhou; Zhiqiang Luo

doi:10.1371/journal.pone.0329062

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Open Access

Peer-reviewed

Research Article

Mediating role of inflammatory markers in the relationship between cotinine levels and total bone mineral density

Lei Huang ,

Contributed equally to this work with: Lei Huang, Xianghong Wang

Roles Conceptualization, Methodology, Software

Affiliation Department of Orthopaedics, Lanzhou University Second Hospital, Lanzhou, Gansu, China
⨯
Xianghong Wang ,

Contributed equally to this work with: Lei Huang, Xianghong Wang

Roles Conceptualization, Methodology, Software

Affiliation Department of Orthopaedics, Gansu Jiuquan Hospital of Traditional Chinese Medicine, Jiuquan, Gansu, China
⨯
Xianxu Zhang,

Roles Data curation, Writing – original draft

Affiliation Department of Orthopaedics, Lanzhou University Second Hospital, Lanzhou, Gansu, China
⨯
Shicheng Li,

Roles Data curation, Writing – original draft

Affiliation Department of Orthopaedics, Lanzhou University Second Hospital, Lanzhou, Gansu, China
⨯
Xin Liu,

Roles Investigation, Visualization

Affiliation Department of Orthopaedics, Lanzhou University Second Hospital, Lanzhou, Gansu, China
⨯
Zhong Ma,

Roles Investigation, Visualization

Affiliation Department of Orthopaedics, Lanzhou University Second Hospital, Lanzhou, Gansu, China
⨯
Bin Qian,

Roles Software, Validation

Affiliation Department of Orthopaedics, Lanzhou University Second Hospital, Lanzhou, Gansu, China
⨯
Changlin Zhou,

Roles Writing – review & editing

Affiliation Department of Orthopaedics, Lanzhou University Second Hospital, Lanzhou, Gansu, China
⨯
Zhiqiang Luo

Roles Conceptualization, Methodology, Software

* E-mail: luozhiq20000@163.com

Affiliation Department of Orthopaedics, Lanzhou University Second Hospital, Lanzhou, Gansu, China

https://orcid.org/0000-0002-5651-3847

⨯

Mediating role of inflammatory markers in the relationship between cotinine levels and total bone mineral density

Lei Huang,
Xianghong Wang,
Xianxu Zhang,
Shicheng Li,
Xin Liu,
Zhong Ma,
Bin Qian,
Changlin Zhou,
Zhiqiang Luo

Published: August 8, 2025
https://doi.org/10.1371/journal.pone.0329062

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