TGFBR1 gene silencing attenuates cardiomyopathy in the HFpEF mouse model

Xuanyang Shen; Weidong Li; Xiaolu Jiang; Hongfu Wen; Yuan Shen; Wen Zhang; Yongjian Peng; Guoping Kang

doi:10.1371/journal.pone.0328981

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Open Access

Peer-reviewed

Research Article

TGFBR1 gene silencing attenuates cardiomyopathy in the HFpEF mouse model

Xuanyang Shen ,

Contributed equally to this work with: Xuanyang Shen, Weidong Li

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliations Department of Emergency, Affiliated Hospital of North Sichuan Medical College, Nanchong, China, Science and Technology Innovation Center of North Sichuan Medical College, Nanchong, China, Department of Emergency, Bazhong central hospital, Bazhong, China
⨯
Weidong Li ,

Contributed equally to this work with: Xuanyang Shen, Weidong Li

Roles Conceptualization, Data curation, Funding acquisition, Writing – original draft, Writing – review & editing

* E-mail: lwd10000@126.com

Affiliation Department of Emergency, Affiliated Hospital of North Sichuan Medical College, Nanchong, China

https://orcid.org/0009-0000-9547-1697

⨯
Xiaolu Jiang,

Roles Data curation, Formal analysis, Investigation, Methodology, Software, Validation

Affiliations Department of Emergency, Affiliated Hospital of North Sichuan Medical College, Nanchong, China, Science and Technology Innovation Center of North Sichuan Medical College, Nanchong, China
⨯
Hongfu Wen,

Roles Data curation, Investigation, Methodology, Software, Validation

Affiliation Department of Emergency, Affiliated Hospital of North Sichuan Medical College, Nanchong, China
⨯
Yuan Shen,

Roles Data curation, Investigation, Software, Validation

Affiliation Department of Emergency, Affiliated Hospital of North Sichuan Medical College, Nanchong, China
⨯
Wen Zhang,

Roles Data curation, Software, Visualization

Affiliation Department of Emergency, Affiliated Hospital of North Sichuan Medical College, Nanchong, China
⨯
Yongjian Peng,

Roles Data curation, Software, Validation

Affiliation Department of Clinical Medicine, North Sichuan Medical College, Nanchong, China
⨯
Guoping Kang

Roles Data curation, Methodology, Software

Affiliation Department of Emergency, Bazhong central hospital, Bazhong, China
⨯

TGFBR1 gene silencing attenuates cardiomyopathy in the HFpEF mouse model

Xuanyang Shen,
Weidong Li,
Xiaolu Jiang,
Hongfu Wen,
Yuan Shen,
Wen Zhang,
Yongjian Peng,
Guoping Kang

Published: August 29, 2025
https://doi.org/10.1371/journal.pone.0328981

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TGF-beta signaling cascade
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Gene silencing
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Mouse models
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Collagens
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Apoptosis
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Fibrosis
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Small interfering RNA
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Protein expression
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