Predicting short-term mortality in severe cirrhosis: An interpretable machine learning model integrating routine clinical indicators

Shun Zhang; Rui Liu; Zhengjie Li; Tao Pan; Xudong Wen

doi:10.1371/journal.pone.0328952

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Open Access

Peer-reviewed

Research Article

Predicting short-term mortality in severe cirrhosis: An interpretable machine learning model integrating routine clinical indicators

Shun Zhang ,

Contributed equally to this work with: Shun Zhang, Rui Liu, Zhengjie Li

Roles Conceptualization, Data curation, Formal analysis, Methodology, Project administration, Supervision, Validation, Writing – original draft

Affiliations Department of Gastroenterology, Chengdu University of Traditional Chinese Medicine Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Chengdu, China, Department of Gastroenterology, Chengdu Integrated TCM & Western Medicine Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, China
⨯
Rui Liu ,

Contributed equally to this work with: Shun Zhang, Rui Liu, Zhengjie Li

Roles Conceptualization, Data curation, Methodology, Software, Supervision, Writing – original draft

Affiliation Department of Gastroenterology, Chengdu Integrated TCM & Western Medicine Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, China
⨯
Zhengjie Li ,

Contributed equally to this work with: Shun Zhang, Rui Liu, Zhengjie Li

Roles Data curation, Formal analysis, Resources, Software, Supervision, Validation, Visualization

Affiliations Department of Gastroenterology, Chengdu University of Traditional Chinese Medicine Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Chengdu, China, Department of Gastroenterology, Chengdu Integrated TCM & Western Medicine Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, China
⨯
Tao Pan ,

Roles Conceptualization, Formal analysis, Supervision, Visualization, Writing – review & editing

* E-mail: pant414@163.com (TP); xudongwen@cdutcm.edu.cn (XW)

Affiliation Department of Gastroenterology, Chengdu Integrated TCM & Western Medicine Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, China

https://orcid.org/0000-0001-9333-1412

⨯
Xudong Wen

Roles Conceptualization, Funding acquisition, Resources, Supervision, Writing – review & editing

* E-mail: pant414@163.com (TP); xudongwen@cdutcm.edu.cn (XW)

Affiliation Department of Gastroenterology, Chengdu Integrated TCM & Western Medicine Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, China

https://orcid.org/0000-0001-5969-1326

⨯

Predicting short-term mortality in severe cirrhosis: An interpretable machine learning model integrating routine clinical indicators

Shun Zhang,
Rui Liu,
Zhengjie Li,
Tao Pan,
Xudong Wen

Published: March 3, 2026
https://doi.org/10.1371/journal.pone.0328952

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Cirrhosis
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Bilirubin
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Blood counts
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