Transcriptomic suppression of immune and ECM stability in skeletal muscle of patients with chronic kidney disease

Luke A. Baker; Nicholas Eastley; Robert U. Ashford; Matthew Denniff; Matthew Graham-Brown; Emma L. Watson

doi:10.1371/journal.pone.0328947

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Open Access

Peer-reviewed

Research Article

Transcriptomic suppression of immune and ECM stability in skeletal muscle of patients with chronic kidney disease

Luke A. Baker,

Roles Project administration, Writing – review & editing

Affiliations Division of Respiratory Sciences, College of Life Sciences, University of Leicester, Leicester, United Kingdom, NIHR Leicester Biomedical Research Centre (BRC), University of Leicester, Leicester, United Kingdom

https://orcid.org/0000-0003-2111-3832

⨯
Nicholas Eastley,

Roles Data curation, Methodology, Writing – review & editing

Affiliations Leicester Orthopaedics, University Hospitals of Leicester, Leicester, United Kingdom, Division of Cancer Sciences, College of Life Sciences, University of Leicester, Leicester, United Kingdom
⨯
Robert U. Ashford,

Roles Data curation, Methodology, Writing – review & editing

Affiliations Leicester Orthopaedics, University Hospitals of Leicester, Leicester, United Kingdom, Division of Cancer Sciences, College of Life Sciences, University of Leicester, Leicester, United Kingdom
⨯
Matthew Denniff,

Roles Data curation, Methodology, Writing – review & editing

Affiliations Division of Respiratory Sciences, College of Life Sciences, University of Leicester, Leicester, United Kingdom, NIHR Leicester Biomedical Research Centre (BRC), University of Leicester, Leicester, United Kingdom
⨯
Matthew Graham-Brown,

Roles Methodology, Writing – review & editing, Data curation

Affiliations NIHR Leicester Biomedical Research Centre (BRC), University of Leicester, Leicester, United Kingdom, Division of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom
⨯
Emma L. Watson

Roles Data curation, Formal analysis, Methodology, Project administration, Validation, Visualization, Writing – review & editing, Conceptualization

* E-mail: emma.watson@leicester.ac.uk

Affiliations NIHR Leicester Biomedical Research Centre (BRC), University of Leicester, Leicester, United Kingdom, Division of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom

https://orcid.org/0000-0002-3869-8972

⨯

Transcriptomic suppression of immune and ECM stability in skeletal muscle of patients with chronic kidney disease

Luke A. Baker,
Nicholas Eastley,
Robert U. Ashford,
Matthew Denniff,
Matthew Graham-Brown,
Emma L. Watson

Published: February 24, 2026
https://doi.org/10.1371/journal.pone.0328947

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Chronic kidney disease
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Gene expression
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Skeletal muscles
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Muscle regeneration
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Gene ontologies
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RNA sequencing
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Sarcopenia
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Transcriptome analysis
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