Recombinant human alpha-N-acetylglucosamine-6-sulfatase delivered to Sanfilippo D mice with repeated intracerebroventricular injections corrects CNS pathology

• Grant L. Austin ,

  Contributed equally to this work with: Grant L. Austin, Feng Wang

  Roles Formal analysis, Investigation, Writing – original draft, Writing – review & editing

  ¶☯ These authors contributed equally to this work.

  Affiliation Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, United States of America

  ⨯
• Feng Wang ,

  Contributed equally to this work with: Grant L. Austin, Feng Wang

  Roles Conceptualization, Formal analysis, Methodology, Writing – review & editing

  ¶☯ These authors contributed equally to this work.

  Affiliation Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, United States of America

  ⨯
• Steven Q. Le,

  Roles Formal analysis, Investigation, Writing – review & editing

  Affiliation Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, United States of America

  ⨯
• Alexander Sorensen,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, United States of America

  https://orcid.org/0009-0004-3335-8399

  ⨯
• Shan Li,

  Roles Formal analysis, Investigation, Writing – review & editing

  Affiliation Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, United States of America

  ⨯
• Lai C. Foong,

  Roles Formal analysis, Investigation, Writing – review & editing

  Affiliation Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, United States of America

  ⨯
• Srikanth Singamsetty,

  Roles Conceptualization, Project administration, Resources, Writing – review & editing

  Affiliation Phoenix Nest Inc., Brooklyn, New York, United States of America

  ⨯
• Jill Wood,

  Roles Conceptualization, Funding acquisition, Project administration, Resources, Writing – review & editing

  Affiliation Phoenix Nest Inc., Brooklyn, New York, United States of America

  ⨯
• Tsui-Fen Chou,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Supervision, Writing – review & editing

  Affiliations Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, United States of America, Proteome Exploration Laboratory, Beckman Institute, California Institute of Technology, Pasadena, California, United States of America

  ⨯
• Patricia I. Dickson

  Roles Conceptualization, Formal analysis, Investigation, Project administration, Resources, Supervision, Writing – review & editing

  * E-mail: pdickson@wustl.edu

  Affiliation Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, United States of America

  https://orcid.org/0000-0003-3467-8488

  ⨯