Depression and weight loss trajectories during an integrated behavioral intervention: Within-treatment analysis of the RAINBOW trial

Bailey W. Osweiler; Daphne Lew; Nan Lv; Jun Ma; Thomas G. Kannampallil

doi:10.1371/journal.pone.0328715

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Open Access

Peer-reviewed

Research Article

Depression and weight loss trajectories during an integrated behavioral intervention: Within-treatment analysis of the RAINBOW trial

Bailey W. Osweiler ,

Roles Conceptualization, Formal analysis, Investigation, Project administration, Visualization, Writing – original draft, Writing – review & editing

¶‡ BO and DL are joint first authors

Affiliation Division of Computational and Data Sciences, McKelvey School of Engineering, Washington University in St. Louis, St. Louis, Missouri, United States of America

https://orcid.org/0009-0005-3179-8136

⨯
Daphne Lew ,

Roles Conceptualization, Methodology, Validation, Writing – original draft, Writing – review & editing

¶‡ BO and DL are joint first authors

Affiliation Institute for Informatics, Data Science, & Biostatistics (I2DB), School of Medicine, Washington University in St. Louis, St. Louis, Missouri, United States of America

https://orcid.org/0000-0001-5433-2367

⨯
Nan Lv,

Roles Conceptualization, Data curation, Writing – review & editing

Affiliation Center for Health Behavior Research, School of Public Health, University of Illinois Chicago, Chicago, Illinois, United States of America
⨯
Jun Ma ,

Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

¶☯ JM and TK are joint senior authors

Affiliation Center for Health Behavior Research, School of Public Health, University of Illinois Chicago, Chicago, Illinois, United States of America
⨯
Thomas G. Kannampallil

Roles Conceptualization, Methodology, Supervision, Writing – original draft, Writing – review & editing

* E-mail: thomas.k@wustl.edu

¶☯ JM and TK are joint senior authors

Affiliations Division of Computational and Data Sciences, McKelvey School of Engineering, Washington University in St. Louis, St. Louis, Missouri, United States of America, Institute for Informatics, Data Science, & Biostatistics (I2DB), School of Medicine, Washington University in St. Louis, St. Louis, Missouri, United States of America

https://orcid.org/0000-0003-4119-4836

⨯

Depression and weight loss trajectories during an integrated behavioral intervention: Within-treatment analysis of the RAINBOW trial

Bailey W. Osweiler,
Daphne Lew,
Nan Lv,
Jun Ma,
Thomas G. Kannampallil

Published: December 19, 2025
https://doi.org/10.1371/journal.pone.0328715

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Body weight
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Depression
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Weight loss
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Blood pressure
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Eating disorders
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