HIV-1 controllers possess a unique CD8⁺ T cell activation phenotype and loss of control is associated with increased expression of exhaustion markers

• Amber D. Jones ,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – original draft

  ¶‡ These authors share first authorship on this work.

  Affiliations Department of Biological Sciences, University of the Sciences, Philadelphia, Pennsylvania, United States of America, Department of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America

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• Zachary Capriotti ,

  Roles Data curation, Formal analysis, Investigation, Methodology, Writing – original draft

  ¶‡ These authors share first authorship on this work.

  Affiliations Department of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America, Molecular and Cell Biology and Genetics Graduate Program, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America

  ⨯
• Erin Santos,

  Roles Investigation, Resources

  Affiliation The Smith Center for Infectious Diseases and Urban Health, West Orange New Jersey, United States of America

  ⨯
• Angel Lin,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America

  ⨯
• Rachel Van Duyne,

  Roles Project administration, Supervision, Writing – review & editing

  Affiliations Department of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America, Center for Neuroimmunology and CNS Therapeutics, Institute for Molecular Medicine and Infectious Diseases, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America

  ⨯
• Stephen Smith,

  Roles Conceptualization, Data curation, Resources, Writing – review & editing

  Affiliation The Smith Center for Infectious Diseases and Urban Health, West Orange New Jersey, United States of America

  https://orcid.org/0000-0002-9158-6136

  ⨯
• Zachary Klase

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Supervision, Writing – review & editing

  * E-mail: zk76@drexel.edu

  Affiliations Department of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America, Center for Neuroimmunology and CNS Therapeutics, Institute for Molecular Medicine and Infectious Diseases, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

  https://orcid.org/0000-0002-2208-5768

  ⨯