Effects of esketamine on postoperative pain, anxiety, depression, sleep, and inflammation in pregnancies undergoing cesarean section: A randomized controlled trial

Yijun Wang; Xiaolu Lin; Xiang Zou; Renqin Zhang; Juanxia Xing; Li Zhang; Jie Shen; Xiaoliang Zhang; Daju Zhou; Junhua Zhang

doi:10.1371/journal.pone.0328585

Loading metrics

Open Access

Peer-reviewed

Research Article

Effects of esketamine on postoperative pain, anxiety, depression, sleep, and inflammation in pregnancies undergoing cesarean section: A randomized controlled trial

Yijun Wang,

Roles Methodology

Affiliation Department of Anesthesiology, Chongqing University Fuling Hospital, Chongqing, China
⨯
Xiaolu Lin,

Roles Writing – original draft

Affiliation Department of Anesthesiology, Chongqing University Fuling Hospital, Chongqing, China
⨯
Xiang Zou,

Roles Methodology

Affiliation Department of Anesthesiology, Chongqing University Fuling Hospital, Chongqing, China
⨯
Renqin Zhang,

Roles Validation

Affiliation Department of Gynecology and Obstetrics, Chongqing University Fuling Hospital, Chongqing, China
⨯
Juanxia Xing,

Roles Resources

Affiliation Department of Clinical Laboratory, Chongqing University Fuling Hospital, Chongqing, China
⨯
Li Zhang,

Roles Software

Affiliation Department of Hospital Infection Management, Chongqing University Fuling Hospital, Chongqing, China
⨯
Jie Shen,

Roles Software

Affiliation Department of Pharmacy, Chongqing University Fuling Hospital, Chongqing, China
⨯
Xiaoliang Zhang,

Roles Investigation

Affiliation Department of Anesthesiology, Chongqing University Fuling Hospital, Chongqing, China
⨯
Daju Zhou ,

Roles Writing – review & editing

* E-mail: okzjh000@163.com (JZ); 276331951@qq.com (DZ)

Affiliation Department of Gynecology and Obstetrics, Chongqing University Fuling Hospital, Chongqing, China
⨯
Junhua Zhang

Roles Project administration

* E-mail: okzjh000@163.com (JZ); 276331951@qq.com (DZ)

Affiliation Department of Anesthesiology, Chongqing University Fuling Hospital, Chongqing, China

https://orcid.org/0009-0006-1099-3183

⨯

Effects of esketamine on postoperative pain, anxiety, depression, sleep, and inflammation in pregnancies undergoing cesarean section: A randomized controlled trial

Yijun Wang,
Xiaolu Lin,
Xiang Zou,
Renqin Zhang,
Juanxia Xing,
Li Zhang,
Jie Shen,
Xiaoliang Zhang,
Daju Zhou,
Junhua Zhang

Published: January 23, 2026
https://doi.org/10.1371/journal.pone.0328585

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Pain
Is the Subject Area "Pain" applicable to this article?

Thanks for your feedback.
Depression
Is the Subject Area "Depression" applicable to this article?

Thanks for your feedback.
Hyperalgesia
Is the Subject Area "Hyperalgesia" applicable to this article?

Thanks for your feedback.
Sleep disorders
Is the Subject Area "Sleep disorders" applicable to this article?

Thanks for your feedback.
Pregnancy
Is the Subject Area "Pregnancy" applicable to this article?

Thanks for your feedback.
Sleep
Is the Subject Area "Sleep" applicable to this article?

Thanks for your feedback.
Hypothyroidism
Is the Subject Area "Hypothyroidism" applicable to this article?

Thanks for your feedback.
Inflammatory diseases
Is the Subject Area "Inflammatory diseases" applicable to this article?

Thanks for your feedback.