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Open Access

Peer-reviewed

Research Article

Integrated bioinformatics and experimental validation identify ATF3 as a key gene in secondary brain damage after intracerebral hemorrhage

Tao Cui,

Roles Data curation, Supervision, Validation, Writing – original draft

Affiliations Department of Neurosurgery, The First Affiliated Hospital of Anhui Medical University, Hefei, China, Department of Neurosurgery, The Taihe County People’s Hospital, Taihe, China

https://orcid.org/0009-0000-9428-6924

⨯
Jinbang Huang,

Roles Data curation, Formal analysis, Investigation, Methodology, Resources

Affiliations Department of Neurosurgery, The First Affiliated Hospital of Anhui Medical University, Hefei, China, Department of Neurosurgery, The Taihe County People’s Hospital, Taihe, China
⨯
Chaoyong Zhang,

Roles Conceptualization, Data curation, Formal analysis, Software, Supervision, Validation

Affiliation Department of Neurosurgery, The Taihe County People’s Hospital, Taihe, China
⨯
Bin Wang

Roles Conceptualization, Writing – review & editing

* E-mail: smu3099@126.com

Affiliation Department of Neurosurgery, The First Affiliated Hospital of Anhui Medical University, Hefei, China
⨯

Integrated bioinformatics and experimental validation identify ATF3 as a key gene in secondary brain damage after intracerebral hemorrhage

Tao Cui,
Jinbang Huang,
Chaoyong Zhang,
Bin Wang

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Published: July 18, 2025
https://doi.org/10.1371/journal.pone.0328530

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Brain damage
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Gene expression
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Hemorrhage
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Platelet activation
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Heme
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Apoptosis
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Genetic networks
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Protein interaction networks
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