LBH589 reduces oxidized mitochondrial DNA and suppresses NLRP3 inflammasome activation to relieve pulmonary inflammation

Changwen Ning; Fenghua Gao; Zhe Wang; Huaying An; Pengyu Liu; Yanan Sun; Ru Li; Zhuyang Song; Yuanyuan Yuan; Jinlong Li; Jun Ma; Xingwei Jiang; Qun Yu

doi:10.1371/journal.pone.0328522

Loading metrics

Open Access

Peer-reviewed

Research Article

LBH589 reduces oxidized mitochondrial DNA and suppresses NLRP3 inflammasome activation to relieve pulmonary inflammation

Changwen Ning ,

Contributed equally to this work with: Changwen Ning, Fenghua Gao, Zhe Wang

Roles Conceptualization, Data curation, Formal analysis, Investigation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Institute of Health Service and Transfusion Medicine, Academy of Military Medical Sciences, Beijing, China
⨯
Fenghua Gao ,

Contributed equally to this work with: Changwen Ning, Fenghua Gao, Zhe Wang

Roles Conceptualization, Data curation, Formal analysis, Writing – original draft

Affiliation Institute of Health Service and Transfusion Medicine, Academy of Military Medical Sciences, Beijing, China
⨯
Zhe Wang ,

Contributed equally to this work with: Changwen Ning, Fenghua Gao, Zhe Wang

Roles Conceptualization, Data curation, Formal analysis, Writing – original draft

Affiliation Institute of Health Service and Transfusion Medicine, Academy of Military Medical Sciences, Beijing, China
⨯
Huaying An,

Roles Investigation, Visualization, Writing – review & editing

Affiliation Institute of Health Service and Transfusion Medicine, Academy of Military Medical Sciences, Beijing, China
⨯
Pengyu Liu,

Roles Investigation, Visualization, Writing – review & editing

Affiliation Institute of Health Service and Transfusion Medicine, Academy of Military Medical Sciences, Beijing, China
⨯
Yanan Sun,

Roles Visualization

Affiliation Institute of Health Service and Transfusion Medicine, Academy of Military Medical Sciences, Beijing, China
⨯
Ru Li,

Roles Visualization

Affiliation Institute of Health Service and Transfusion Medicine, Academy of Military Medical Sciences, Beijing, China
⨯
Zhuyang Song,

Roles Visualization

Affiliation Institute of Health Service and Transfusion Medicine, Academy of Military Medical Sciences, Beijing, China
⨯
Yuanyuan Yuan,

Roles Visualization

Affiliation Institute of Health Service and Transfusion Medicine, Academy of Military Medical Sciences, Beijing, China
⨯
Jinlong Li,

Roles Visualization

Affiliation Institute of Health Service and Transfusion Medicine, Academy of Military Medical Sciences, Beijing, China
⨯
Jun Ma ,

Roles Investigation, Project administration, Supervision, Writing – review & editing

* E-mail: yuqun1970@outlook.com (QY); 13910216274@163.com (XJ); cooboy_241@163.com (JM)

¶‡ JM, XJ and QY also contributed equally to this work.

Affiliation Institute of Health Service and Transfusion Medicine, Academy of Military Medical Sciences, Beijing, China
⨯
Xingwei Jiang ,

Roles Investigation, Project administration, Supervision, Writing – review & editing

* E-mail: yuqun1970@outlook.com (QY); 13910216274@163.com (XJ); cooboy_241@163.com (JM)

¶‡ JM, XJ and QY also contributed equally to this work.

Affiliation Institute of Health Service and Transfusion Medicine, Academy of Military Medical Sciences, Beijing, China
⨯
Qun Yu

Roles Investigation, Project administration, Supervision, Writing – review & editing

* E-mail: yuqun1970@outlook.com (QY); 13910216274@163.com (XJ); cooboy_241@163.com (JM)

¶‡ JM, XJ and QY also contributed equally to this work.

Affiliation Institute of Health Service and Transfusion Medicine, Academy of Military Medical Sciences, Beijing, China

https://orcid.org/0000-0001-6501-3046

⨯

LBH589 reduces oxidized mitochondrial DNA and suppresses NLRP3 inflammasome activation to relieve pulmonary inflammation

Changwen Ning,
Fenghua Gao,
Zhe Wang,
Huaying An,
Pengyu Liu,
Yanan Sun,
Ru Li,
Zhuyang Song,
Yuanyuan Yuan,
Jinlong Li

Published: August 4, 2025
https://doi.org/10.1371/journal.pone.0328522

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Inflammasomes
Is the Subject Area "Inflammasomes" applicable to this article?

Thanks for your feedback.
Inflammation
Is the Subject Area "Inflammation" applicable to this article?

Thanks for your feedback.
Mitochondrial DNA
Is the Subject Area "Mitochondrial DNA" applicable to this article?

Thanks for your feedback.
Cytokines
Is the Subject Area "Cytokines" applicable to this article?

Thanks for your feedback.
Enzyme-linked immunoassays
Is the Subject Area "Enzyme-linked immunoassays" applicable to this article?

Thanks for your feedback.
Cytokine therapy
Is the Subject Area "Cytokine therapy" applicable to this article?

Thanks for your feedback.
Macrophages
Is the Subject Area "Macrophages" applicable to this article?

Thanks for your feedback.
Mitochondria
Is the Subject Area "Mitochondria" applicable to this article?

Thanks for your feedback.