Advanced microfluidic and 3D cell culture platforms for modeling vascularization in diabetic foot ulcers: A systematic review of translational challenges and perspectives

• Ana Karoline Almeida da Silva ,

  Contributed equally to this work with: Ana Karoline Almeida da Silva, Suélia de Siqueira Rodrigues Fleury Rosa

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: anakaroline.alms@gmail.com

  Affiliation University of Brasilia - UnB, Campus Darcy Ribeiro, Postgraduate Programme in Mechatronic Systems, Mechanical Engineering Department, Brasilia, Distrito Federal, Brazil

  https://orcid.org/0000-0001-9340-6568

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• Gustavo Adolfo Marcelino de Almeida Nunes ,

  Roles Conceptualization, Data curation, Investigation, Methodology, Writing – original draft, Writing – review & editing

  ¶‡ These authors also contributed equally to this work.

  Affiliation University of Brasilia - UnB, Campus Darcy Ribeiro, Postgraduate Programme in Mechatronic Systems, Mechanical Engineering Department, Brasilia, Distrito Federal, Brazil

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• Rafael Mendes Faria ,

  Roles Conceptualization, Data curation, Methodology, Resources, Writing – original draft

  ¶‡ These authors also contributed equally to this work.

  Affiliation Federal Institute of Education, Science and Technology of Triângulo Mineiro - IFTM, Campus Paracatu, Department of Electrical Engineering, Paracatu, Minas Gerais, Brazil

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• Klériston Santos,

  Roles Conceptualization, Methodology, Writing – original draft, Writing – review & editing

  Affiliations University of Brasilia - UnB, Campus Darcy Ribeiro, Postgraduate Programme in Mechatronic Systems, Mechanical Engineering Department, Brasilia, Distrito Federal, Brazil, Federal Institute of Education, Science and Technology of Triângulo Mineiro - IFTM, Campus Paracatu, Department of Electrical Engineering, Paracatu, Minas Gerais, Brazil

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• Rafael Pissinati de Souza,

  Roles Conceptualization, Data curation, Methodology, Writing – original draft

  Affiliations University of Brasilia - UnB, Campus Darcy Ribeiro, Postgraduate Programme in Mechatronic Systems, Mechanical Engineering Department, Brasilia, Distrito Federal, Brazil, Federal Institute of Education, Science and Technology of Rondônia, Porto Velho, Rondônia, Brazil

  ⨯
• Lindemberg Barreto Mota da Costa,

  Roles Conceptualization, Investigation, Methodology, Writing – original draft

  Affiliation University of Brasilia - Postgraduate Program in Biomedical Engineering-PPGEB, Faculty of Engineering Sciences and Technologies - FCTE, Gama, Distrito Federal, Brazil

  ⨯
• Marcos Augusto M. Fonseca,

  Roles Conceptualization, Data curation, Investigation, Methodology, Visualization, Writing – original draft

  Affiliation University of Brasilia - UnB, Campus Darcy Ribeiro, Postgraduate Programme in Mechatronic Systems, Mechanical Engineering Department, Brasilia, Distrito Federal, Brazil

  ⨯
• Sheila Sousa Gomes Fortes,

  Roles Conceptualization, Methodology, Supervision, Writing – review & editing

  Affiliation University of São Paulo - USP, Institute of Chemistry of São Carlos, Department of Chemistry and Molecular Physics, São Carlos, São Paulo, Brazil

  https://orcid.org/0009-0000-0482-9279

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• Amanda Maciel Lima,

  Roles Conceptualization, Methodology, Writing – original draft, Writing – review & editing

  Affiliation University of São Paulo - USP, Institute of Chemistry of São Carlos, Department of Chemistry and Molecular Physics, São Carlos, São Paulo, Brazil

  ⨯
• Isolda Monteiro,

  Roles Conceptualization, Data curation, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation University of São Paulo - USP, Institute of the Sea, Department of Bioproducts and Bioprocesses, Santos, São Paulo, Brazil

  https://orcid.org/0009-0002-6000-4700

  ⨯
• Pedro Henrique Almeida,

  Roles Conceptualization, Methodology, Writing – review & editing

  Affiliation Federal University of Ceará – UFC, Physical Therapist, Center for Research and Technological Innovations in Human Rehabilitation – INOVAFISIO, Fortaleza, Ceará, Brazil

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• Ana Carolina Migliorini Figueira,

  Roles Writing – original draft, Writing – review & editing

  Affiliation National Center for Research in Energy and Materials - CNPEM, National Laboratory of Biosciences - LNBIO, Campinas, São Paulo, Brazil

  ⨯
• Harsson S. Santana,

  Roles Conceptualization, Investigation, Methodology, Validation, Visualization, Writing – review & editing

  Affiliation Renato Archer Information Technology Center, Campinas, São Paulo, Brazil

  ⨯
• Marcella Lemos Brettas Carneiro,

  Roles Conceptualization, Data curation, Validation, Visualization, Writing – review & editing

  Affiliations University of Brasilia - Postgraduate Program in Biomedical Engineering-PPGEB, Faculty of Engineering Sciences and Technologies - FCTE, Gama, Distrito Federal, Brazil, University of Brasilia - UnB, Campus Ceilândia, Postgraduate Program in Nanoscience and Nanobiotechnology and Postgraduate Program in Health Sciences and Technologies, Ceilândia, Distrito Federal, Brazil

  https://orcid.org/0000-0002-6165-0969

  ⨯
• Glécia Virgolino da Silva Luz,

  Roles Conceptualization, Data curation, Methodology, Writing – review & editing

  Affiliation University of Brasilia - Postgraduate Program in Biomedical Engineering-PPGEB, Faculty of Engineering Sciences and Technologies - FCTE, Gama, Distrito Federal, Brazil

  https://orcid.org/0000-0002-5385-6174

  ⨯
• Graziella Joanitti,

  Roles Conceptualization, Data curation, Writing – review & editing

  Affiliations University of Brasilia - Postgraduate Program in Biomedical Engineering-PPGEB, Faculty of Engineering Sciences and Technologies - FCTE, Gama, Distrito Federal, Brazil, University of Brasilia - UnB, Campus Ceilândia, Postgraduate Program in Nanoscience and Nanobiotechnology and Postgraduate Program in Health Sciences and Technologies, Ceilândia, Distrito Federal, Brazil

  ⨯
• José Carlos Tatmatsu-Rocha,

  Roles Conceptualization, Data curation, Methodology, Writing – review & editing

  Affiliations Federal University of Ceará – UFC, Physical Therapist, Center for Research and Technological Innovations in Human Rehabilitation – INOVAFISIO, Fortaleza, Ceará, Brazil, Federal University of Ceara – UFC, Medicine School, Postgraduate Programs in Biomedical Engineering and in Physiotherapy and Functionality, Fortaleza, Ceara, Brazil

  ⨯
• Mário Fabrício Fleury Rosa,

  Roles Conceptualization, Methodology, Validation, Writing – original draft, Writing – review & editing

  Affiliation University of Brasilia - Postgraduate Program in Biomedical Engineering-PPGEB, Faculty of Engineering Sciences and Technologies - FCTE, Gama, Distrito Federal, Brazil

  ⨯
• Maria Alice Martins,

  Roles Writing – review & editing

  Affiliation Nanotechnology National Laboratory for Agriculture, Embrapa Instrumentation, São Carlos, São Paulo, Brazil

  https://orcid.org/0000-0002-6416-6929

  ⨯
• Ícaro Santos,

  Roles Conceptualization, Writing – review & editing

  Affiliation University of Wisconsin-Madison, Department of Biomedical Engineering, Madison, Wisconsin, United States of America

  ⨯
• Emanuel Carrilho,

  Roles Conceptualization, Data curation, Investigation, Writing – review & editing

  Affiliations University of São Paulo - USP, Institute of Chemistry of São Carlos, Department of Chemistry and Molecular Physics, São Carlos, São Paulo, Brazil, National Institute of Science and Technology in Bioanalytics - Lauro Kubota, Campinas, São Paulo, Brazil

  ⨯
• Adson Ferreira da Rocha,

  Roles Formal analysis, Writing – original draft, Writing – review & editing

  Affiliation University of Brasilia - Postgraduate Program in Biomedical Engineering-PPGEB, Faculty of Engineering Sciences and Technologies - FCTE, Gama, Distrito Federal, Brazil

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•  [ ... ],
• Suélia de Siqueira Rodrigues Fleury Rosa

  Contributed equally to this work with: Ana Karoline Almeida da Silva, Suélia de Siqueira Rodrigues Fleury Rosa

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations University of Brasilia - UnB, Campus Darcy Ribeiro, Postgraduate Programme in Mechatronic Systems, Mechanical Engineering Department, Brasilia, Distrito Federal, Brazil, University of Brasilia - Postgraduate Program in Biomedical Engineering-PPGEB, Faculty of Engineering Sciences and Technologies - FCTE, Gama, Distrito Federal, Brazil, Meinig School of Biomedical Engineering, Master of engineering (M.Eng.) Program, Cornell University, Ithaca, New York, United States of America

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