Novel thiazole derivatives as effective anti-cancer agents against human osteosarcoma cell line (SaOS-2): Microwave-assisted one-pot three-component synthesis, in vitro anti-cancer studies, and in silico investigations

• Arif Mermer ,

  Roles Conceptualization, Writing – original draft, Writing – review & editing

  * E-mail: arif.mermer@sbu.edu.tr (AM); fawad.zahoor@gcuf.edu.pk (AFZ); mezaki@imamu.edu.sa (MEAZ)

  Affiliations Department of Biotechnology, University of Health Sciences, Istanbul, Türkiye, Experimental Medicine Application & Research Center, Validebağ Research Park, University of Health Sciences, Istanbul, Türkiye

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• Aydın Tahmasebifar,

  Roles Resources, Validation, Writing – review & editing

  Affiliations Department of Tissue Engineering, University of Health Sciences, Istanbul, Türkiye, Department of Biomaterials, University of Health Sciences Turkey, Istanbul, Türkiye

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• Sami A. Al-Hussain,

  Roles Funding acquisition, Resources, Writing – review & editing

  Affiliation Department of Chemistry, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia

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• Gizem Tatar Yılmaz,

  Roles Methodology, Resources, Writing – review & editing

  Affiliations Department of Biostatistics and Medical Informatics, Faculty of Medicine, Karadeniz Technical University, Trabzon, Türkiye, Department of Bioinformatics, Karadeniz Technical University, Institute of Health Sciences, Trabzon, Türkiye, Yılmaz Bilişim R&D Consulting Software Engineering and Services Trade Limited Company, Trabzon, Turkey

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• Zeynep Dilan Turgut,

  Roles Investigation, Methodology, Writing – original draft

  Affiliation Department of Bioinformatics, Karadeniz Technical University, Institute of Health Sciences, Trabzon, Türkiye

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• Aqsa Mushtaq,

  Roles Funding acquisition, Writing – review & editing

  Affiliation Department of Chemistry, Government College University Faisalabad, Faisalabad, Pakistan

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• Ameer Fawad Zahoor ,

  Roles Funding acquisition, Writing – review & editing

  * E-mail: arif.mermer@sbu.edu.tr (AM); fawad.zahoor@gcuf.edu.pk (AFZ); mezaki@imamu.edu.sa (MEAZ)

  Affiliation Department of Chemistry, Government College University Faisalabad, Faisalabad, Pakistan

  https://orcid.org/0000-0003-2127-8848

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• Ali Irfan,

  Roles Funding acquisition, Resources, Writing – review & editing

  Affiliation Department of Chemistry, Government College University Faisalabad, Faisalabad, Pakistan

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• Magdi E. A. Zaki

  Roles Funding acquisition, Project administration, Writing – review & editing

  * E-mail: arif.mermer@sbu.edu.tr (AM); fawad.zahoor@gcuf.edu.pk (AFZ); mezaki@imamu.edu.sa (MEAZ)

  Affiliation Department of Chemistry, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia

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