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Open Access
Peer-reviewed
Research Article
Immunohistochemistry guided segmentation of benign epithelial cells, in situ lesions, and invasive epithelial cells in breast cancer slides
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Maren Høibø ,
Roles Methodology, Software, Writing – original draft, Writing – review & editing
* E-mail: maren.hoibo@ntnu.no
Affiliations Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway, Clinic of Laboratory Medicine, St. Olavs hospital, Trondheim University Hospital, Trondheim, Norway
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André Pedersen,
Roles Methodology, Software, Writing – original draft, Writing – review & editing
Affiliations Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway, Clinic of Surgery, St. Olavs hospital, Trondheim University Hospital, Trondheim, Norway, Department of Health Research, SINTEF Digital, Trondheim, Norway, Application Solutions, Sopra Steria, Trondheim, Norway
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Vibeke Grotnes Dale,
Roles Data curation, Writing – review & editing
Affiliations Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway, Department of Pathology, St. Olavs hospital, Trondheim University Hospital, Trondheim, Norway
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Sissel Marie Berget,
Roles Data curation, Writing – review & editing
Affiliation Department of Pathology, St. Olavs hospital, Trondheim University Hospital, Trondheim, Norway
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Borgny Ytterhus,
Roles Data curation, Writing – review & editing
Affiliation Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway
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Cecilia Lindskog,
Roles Data curation, Writing – review & editing
Affiliation Department of Immunology, Genetics and Pathology, Cancer Precision Medicine Research unit, Uppsala University, Uppsala, Sweden
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Elisabeth Wik,
Roles Data curation, Methodology, Writing – review & editing
Affiliations Centre for Cancer Biomarkers CCBIO, Department of Clinical Medicine, University of Bergen, Bergen, Norway, Department of Pathology, Haukeland University Hospital, Bergen, Norway
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Lars A. Akslen,
Roles Data curation, Funding acquisition, Methodology, Writing – review & editing
Affiliations Centre for Cancer Biomarkers CCBIO, Department of Clinical Medicine, University of Bergen, Bergen, Norway, Department of Pathology, Haukeland University Hospital, Bergen, Norway
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Ingerid Reinertsen,
Roles Methodology, Supervision, Writing – original draft, Writing – review & editing
Affiliations Department of Health Research, SINTEF Digital, Trondheim, Norway, Department of Circulation and Medical Imaging, Norwegian University of Science and Technology (NTNU), Trondheim, Norway
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Erik Smistad,
Roles Methodology, Software, Supervision, Writing – original draft, Writing – review & editing
Affiliations Department of Health Research, SINTEF Digital, Trondheim, Norway, Department of Circulation and Medical Imaging, Norwegian University of Science and Technology (NTNU), Trondheim, Norway
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Marit Valla
Roles Data curation, Funding acquisition, Methodology, Supervision, Writing – original draft, Writing – review & editing
Affiliations Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway, Clinic of Laboratory Medicine, St. Olavs hospital, Trondheim University Hospital, Trondheim, Norway
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Immunohistochemistry guided segmentation of benign epithelial cells, in situ lesions, and invasive epithelial cells in breast cancer slides
- Maren Høibø,
- André Pedersen,
- Vibeke Grotnes Dale,
- Sissel Marie Berget,
- Borgny Ytterhus,
- Cecilia Lindskog,
- Elisabeth Wik,
- Lars A. Akslen,
- Ingerid Reinertsen,
- Erik Smistad
- Published: July 17, 2025
- https://doi.org/10.1371/journal.pone.0328033