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Open Access
Peer-reviewed
Research Article
Ischemic duration determines extent of cardiac remodeling, and both early and delayed reperfusion prevent fatal cardiac rupture: Model comparison
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Ling Zhao ,
Contributed equally to this work with: Ling Zhao, Amanguli Ruze
Roles Data curation, Investigation, Methodology, Validation, Writing – original draft
Affiliations Department of Cardiology, State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asian, First Affiliated Hospital, Clinical Medical Research Institute of Xinjiang Medical University, Urumqi, China, Xinjiang Key Laboratory of Medical Animal Model Research, Urumqi, China
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Amanguli Ruze ,
Contributed equally to this work with: Ling Zhao, Amanguli Ruze
Roles Investigation, Project administration, Validation
Affiliations Department of Cardiology, State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asian, First Affiliated Hospital, Clinical Medical Research Institute of Xinjiang Medical University, Urumqi, China, Xinjiang Key Laboratory of Medical Animal Model Research, Urumqi, China
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Guo-Li Du,
Roles Formal analysis, Visualization
Affiliations Department of Cardiology, State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asian, First Affiliated Hospital, Clinical Medical Research Institute of Xinjiang Medical University, Urumqi, China, Xinjiang Key Laboratory of Medical Animal Model Research, Urumqi, China, Department of Endocrinology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China
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Min-Tao Gai,
Roles Validation
Affiliations Department of Cardiology, State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asian, First Affiliated Hospital, Clinical Medical Research Institute of Xinjiang Medical University, Urumqi, China, Xinjiang Key Laboratory of Medical Animal Model Research, Urumqi, China, Xinjiang Key Laboratory of Cardiovascular Disease, Urumqi, China
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Jing Tang,
Roles Formal analysis
Affiliations Department of Cardiology, State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asian, First Affiliated Hospital, Clinical Medical Research Institute of Xinjiang Medical University, Urumqi, China, Xinjiang Key Laboratory of Medical Animal Model Research, Urumqi, China, Department of Clinical Laboratory, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China
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Xiao-Ming Gao
Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing
* E-mail: xiaoming.gao@xjmu.edu.cn
Affiliations Department of Cardiology, State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asian, First Affiliated Hospital, Clinical Medical Research Institute of Xinjiang Medical University, Urumqi, China, Xinjiang Key Laboratory of Medical Animal Model Research, Urumqi, China, Xinjiang Key Laboratory of Cardiovascular Disease, Urumqi, China
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Ischemic duration determines extent of cardiac remodeling, and both early and delayed reperfusion prevent fatal cardiac rupture: Model comparison
- Ling Zhao,
- Amanguli Ruze,
- Guo-Li Du,
- Min-Tao Gai,
- Jing Tang,
- Xiao-Ming Gao
- Published: August 22, 2025
- https://doi.org/10.1371/journal.pone.0328001