Circadian rhythm genes and immune cell infiltration in myasthenia gravis: A comprehensive analysis

Ke Wang; Peng Xu; Jing Lu; Xinchen Ji; Ying Zhang; Yibin Zhang; Dongxu Li; Dongmei Zhang; Tianye Lan; Jian Wang

doi:10.1371/journal.pone.0327829

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Open Access

Peer-reviewed

Research Article

Circadian rhythm genes and immune cell infiltration in myasthenia gravis: A comprehensive analysis

Ke Wang ,

Contributed equally to this work with: Ke Wang, Peng Xu

Roles Data curation, Formal analysis, Methodology, Software, Validation, Writing – original draft

Affiliation College of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, China
⨯
Peng Xu ,

Contributed equally to this work with: Ke Wang, Peng Xu

Roles Conceptualization, Funding acquisition, Methodology, Writing – review & editing

Affiliation Department of Neurology, The Affiliated Hospital to Changchun University to Chinese Medicine, Changchun, China
⨯
Jing Lu,

Roles Formal analysis, Methodology, Resources, Validation

Affiliation Research Center of Traditional Chinese Medicine, The Affiliated Hospital to Changchun University to Chinese Medicine, Changchun, China
⨯
Xinchen Ji,

Roles Data curation, Formal analysis

Affiliation College of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, China
⨯
Ying Zhang,

Roles Data curation, Investigation, Resources

Affiliation Department of Neurology, The Affiliated Hospital to Changchun University to Chinese Medicine, Changchun, China
⨯
Yibin Zhang,

Roles Data curation, Funding acquisition, Investigation, Resources

Affiliation Department of Neurology, The Affiliated Hospital to Changchun University to Chinese Medicine, Changchun, China
⨯
Dongxu Li,

Roles Data curation, Investigation, Resources

Affiliation Department of Neurology, The Affiliated Hospital to Changchun University to Chinese Medicine, Changchun, China
⨯
Dongmei Zhang,

Roles Methodology

Affiliation Scientific Research Office, The Affiliated Hospital to Changchun University to Chinese Medicine, Changchun, China
⨯
Tianye Lan ,

Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

* E-mail: lantianye-x@163.com (TL); jian-w222@163.com (JW)

Affiliation Department of Neurology, The Affiliated Hospital to Changchun University to Chinese Medicine, Changchun, China
⨯
Jian Wang

Roles Conceptualization, Supervision, Writing – review & editing

* E-mail: lantianye-x@163.com (TL); jian-w222@163.com (JW)

Affiliation Department of Neurology, The Affiliated Hospital to Changchun University to Chinese Medicine, Changchun, China

https://orcid.org/0000-0003-1748-7305

⨯

Circadian rhythm genes and immune cell infiltration in myasthenia gravis: A comprehensive analysis

Ke Wang,
Peng Xu,
Jing Lu,
Xinchen Ji,
Ying Zhang,
Yibin Zhang,
Dongxu Li,
Dongmei Zhang,
Tianye Lan,
Jian Wang

Published: July 7, 2025
https://doi.org/10.1371/journal.pone.0327829

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Circadian rhythms
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Myasthenia gravis
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Immune cells
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Circadian oscillators
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Mitochondria
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Sleep
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Gene expression
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Pathogenesis
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