MDMA-assisted therapy and current treatment options for chronic, treatment-resistant, moderate or higher severity post-traumatic stress disorder: Systematic literature review

Filip Stanicic; Vladimir Zah; Dimitrije Grbic; Djurdja Vukicevic; Debra de Angelo

doi:10.1371/journal.pone.0327778

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Peer-reviewed

Research Article

MDMA-assisted therapy and current treatment options for chronic, treatment-resistant, moderate or higher severity post-traumatic stress disorder: Systematic literature review

Filip Stanicic ,

Contributed equally to this work with: Filip Stanicic, Dimitrije Grbic

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation ZRx Outcomes Research Inc., Cawthra Rd, Mississauga, Canada
⨯
Vladimir Zah ,

Roles Conceptualization, Investigation, Project administration, Resources, Software, Supervision, Validation, Writing – review & editing

* E-mail: vzah@outcomesresearch.com

¶‡ VZ, DV, DA authors also contributed equally to this work.

Affiliation ZRx Outcomes Research Inc., Cawthra Rd, Mississauga, Canada

https://orcid.org/0000-0003-1368-4491

⨯
Dimitrije Grbic ,

Contributed equally to this work with: Filip Stanicic, Dimitrije Grbic

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation ZRx Outcomes Research Inc., Cawthra Rd, Mississauga, Canada
⨯
Djurdja Vukicevic ,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – review & editing

¶‡ VZ, DV, DA authors also contributed equally to this work.

Affiliation ZRx Outcomes Research Inc., Cawthra Rd, Mississauga, Canada
⨯
Debra de Angelo

Roles Conceptualization, Funding acquisition, Resources, Supervision, Validation, Writing – review & editing

¶‡ VZ, DV, DA authors also contributed equally to this work.

Affiliation Lykos Therapeutics, Stevens Creek Blvd, San Jose, California, United States of America
⨯

MDMA-assisted therapy and current treatment options for chronic, treatment-resistant, moderate or higher severity post-traumatic stress disorder: Systematic literature review

Filip Stanicic,
Vladimir Zah,
Dimitrije Grbic,
Djurdja Vukicevic,
Debra de Angelo

Published: July 16, 2025
https://doi.org/10.1371/journal.pone.0327778

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Psychotherapy
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