A novel Leishmania infantum reference strain for gene editing and the study of visceral leishmaniasis

Rokhaya Thiam; Maria Santana Ceballos; Tom Beneke; Nada Kuk; Grégoire Pasquier; Lucien Crobu; Daniel C. Jeffares; Baptiste Vergnes; Bridlin Barckmann; Yvon Sterkers

doi:10.1371/journal.pone.0327390

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Open Access

Peer-reviewed

Research Article

A novel Leishmania infantum reference strain for gene editing and the study of visceral leishmaniasis

Rokhaya Thiam,

Roles Formal analysis, Investigation, Methodology, Software, Visualization, Writing – original draft

Affiliation University of Montpellier, CNRS, IRD, Academic Hospital (CHU) of Montpellier, MiVEGEC, Montpellier, France
⨯
Maria Santana Ceballos,

Roles Investigation

Affiliation University of Montpellier, CNRS, IRD, Academic Hospital (CHU) of Montpellier, MiVEGEC, Montpellier, France
⨯
Tom Beneke,

Roles Software, Writing – review & editing

Affiliation Department of Cell and Developmental Biology, Biocentre, University of Würzburg, Würzburg, Germany
⨯
Nada Kuk,

Roles Investigation, Resources

Affiliation University of Montpellier, CNRS, IRD, Academic Hospital (CHU) of Montpellier, MiVEGEC, Montpellier, France
⨯
Grégoire Pasquier,

Roles Formal analysis, Investigation, Software

Affiliation University of Montpellier, CNRS, IRD, Academic Hospital (CHU) of Montpellier, MiVEGEC, Montpellier, France
⨯
Lucien Crobu,

Roles Investigation

Affiliation University of Montpellier, CNRS, IRD, Academic Hospital (CHU) of Montpellier, MiVEGEC, Montpellier, France
⨯
Daniel C. Jeffares,

Roles Resources, Writing – review & editing

Affiliation Department of Biology and York Biomedical Research Institute, University of York, York United Kingdom
⨯
Baptiste Vergnes,

Roles Resources, Writing – review & editing

Affiliation University of Montpellier, CNRS, IRD, Academic Hospital (CHU) of Montpellier, MiVEGEC, Montpellier, France
⨯
Bridlin Barckmann,

Roles Data curation, Methodology, Software, Writing – original draft, Writing – review & editing

Affiliation University of Montpellier, CNRS, IRD, Academic Hospital (CHU) of Montpellier, MiVEGEC, Montpellier, France
⨯
Yvon Sterkers

Roles Conceptualization, Data curation, Funding acquisition, Methodology, Project administration, Supervision, Validation, Writing – original draft, Writing – review & editing

* E-mail: yvon.sterkers@umontpellier.fr

Affiliation University of Montpellier, CNRS, IRD, Academic Hospital (CHU) of Montpellier, MiVEGEC, Montpellier, France

https://orcid.org/0000-0002-5623-5664

⨯

A novel Leishmania infantum reference strain for gene editing and the study of visceral leishmaniasis

Rokhaya Thiam,
Maria Santana Ceballos,
Tom Beneke,
Nada Kuk,
Grégoire Pasquier,
Lucien Crobu,
Daniel C. Jeffares,
Baptiste Vergnes,
Bridlin Barckmann,
Yvon Sterkers

Published: September 3, 2025
https://doi.org/10.1371/journal.pone.0327390

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Genomics
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Leishmania infantum
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Parasitic diseases
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Leishmania donovani
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